Postinfectional inhibitors from plants. XV. Antifungal activity of the phytoalexin orchinol and related phenanthrenes and stilbenes
Postinfectional inhibitors from plants. XV. Antifungal activity of the phytoalexin orchinol and related phenanthrenes and stilbenes
复制标题
来自植物的感染后抑制剂。
作者：
E. Ward;C. Unwin;A. Stoessl
对实验室合成的冬青酚、氯格洛索尔和几种相关的菲和二苯乙烯类化合物进行了抗真菌活性的测试，主要是在孢子萌发试验中对果白念珠菌和疫霉的抑制活性。其中活性最强的二苯乙烯为3，5-二甲氧基-3‘-羟基二苯乙烯(平均有效剂量(ED50)5 × 10−5 M)，至少与报道的二苯乙烯类植物保卫素Pinosylvin的活性相当。所有被测试的菲和二氢菲都是活性的，尽管分析因溶解度问题而变得复杂。冬凌草酚的ED50为(5 × 10−5 M)，氯格列醇具有相似的抗疫霉菌活性。有几种菲具有较高的活性，其中以脱氢冬青酚最为显著(ED50vs.侵染疫霉5 × 10−6 M)，值得进一步研究。试验真菌对菲和二氢菲的反应的一个显著特征是产生扭曲和破裂的芽管，这可能表明直接干扰了顶端的生长过程。没有证据..。
Orchinol, loroglossol, and several related phenanthrenes and stilbenes obtained by laboratory synthesis were tested for antifungal activity, primarily in spore germination assays against Monilinia fructicola and Phytophthora infestons. The most active stilbene tested was 3,5-dimethoxy-3′-hydroxystilbene (mean effective dose (ED50) 5 × 10−5 M), at least comparable with the reported activity of the stilbene phytoalexin, pinosylvin. All the phenanthrenes and dihydrophenanthrenes tested were active, although assays were complicated by solubility problems. ED50 for orchinol was (5 × 10−5 M) and loroglossol had similar activity against P. infestons. Several phenanthrenes had higher activity, notably dehydroorchinol (ED50 vs. P. infestons 5 × 10−6 M), and warrant further study. A striking feature of the response of the test fungi to the phenanthrenes and dihydrophenanthrenes was the production of distorted and ruptured germ tubes, which may indicate a direct interference with growth processes at the tip. No evid...