Dose-dependent behavior of bioactive glass dissolution
Dose-dependent behavior of bioactive glass dissolution
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DOI：
10.1002/jbm.10053
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发表时间：
2001-12-05
期刊：
影响因子：
--
通讯作者：
Hench, LL
中科院分区：
文献类型：
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作者：
Jones, JR;Sepulveda, P;Hench, LL
研究了玻璃用量（0.001 g ml（-1）~ 0.015 g ml（-1））对熔融45 S5和溶胶-凝胶58 S生物活性玻璃在37 ℃模拟体液（SBF）中的体外动态溶解行为的影响。这些玻璃的质地，特别是比表面积和孔隙率，由于制造路线的差异而显著不同。元素（Si，Ca，P和Na）的浓度从玻璃浸出到溶解介质中，从1到22小时，进行了评价与使用诱导耦合等离子体分析（ICP）。利用FTIR分析反应后的粉末，观察在表面上形成的羟基碳酸磷灰石层。结果表明，HCA的形成率在两个凝胶和熔融衍生的生物活性玻璃粉末在体外取决于溶液中的粉末的浓度。在进行体外细胞培养研究以模拟体内条件和使用生物活性玻璃粉末提取物进行实验时，必须考虑到这一结果。(C)John Wiley & Sons，Inc.
The effect of glass dosage (0.001 g ml(-1) to 0.015 g ml(-1)) on the in vitro dynamic dissolution behavior of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses, in simulated body fluid (SBF) at 37 degreesC, was evaluated. These glasses differ significantly in texture, especially the specific surface area and porosity, as a result of differences in manufacturing route. The concentrations of elements (Si, Ca, P, and Na) leached from the glasses into the dissolution medium, from 1 to 22 h, were evaluated with the use of induced coupled plasma analysis (ICP). The reacted powders were analyzed with the use of FTIR to observe the formation of a hydroxycarbonate apatite layer on the surface. The results show that the rate of HCA formation on both gel- and melt-derived bioactive glass powders in vitro depends on the concentration of the powders in solution. This result must be taken into account when carrying out in vitro cell-culture studies to simulate conditions in vivo and in experiments using extracts of the bioactive glass powders. (C) 2001 John Wiley & Sons, Inc.