Examination of the melatonin hypothesis in women exposed at night to EMF or bright light
Examination of the melatonin hypothesis in women exposed at night to EMF or bright light
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DOI：
10.2307/3454709
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发表时间：
2001-05-01
影响因子：
10.4
通讯作者：
Sastre, A
中科院分区：
文献类型：
--
作者：
Graham, C;Cook, MR;Sastre, A
据推测，工业社会中乳腺癌发病率的增加与更多地暴露于工频电场和磁场（EMF）和/或夜间高水平光照（LAN）有关。据说电磁场和局域网会降低循环中褪黑激素的水平，从而使雌激素水平上升，刺激乳腺上皮干细胞的更新，并增加恶性转化的风险。三个实验室为基础的研究，其中共有53名健康的年轻女性在夜间暴露于EMF或LAN控制暴露条件下，进行，以确定是否这样的曝光减少褪黑激素，并与进一步改变雌激素。整夜暴露于工业强度磁场（60 Hz，28.3 μ T）对褪黑激素或雌二醇的血液水平没有影响。与此相反，夜间褪黑激素水平被深深地抑制，并在女性暴露于LAN的峰值浓度的时间显着延迟，无论他们是在卵泡期或黄体期的月经周期。然而，这些变化与雌二醇逐点匹配测量的改变无关。每晚长期分泌大量或少量褪黑激素的女性（曲线下面积范围：86- 1，296 pg/mL）的血液雌二醇水平也没有差异。总之，这些结果与越来越多的证据一致，这些证据通常表明环境EMF暴露对本报告中测量的参数几乎没有影响。
It has been hypothesized that the increased incidence of breast cancer in industrial societies is related to greater exposure to power-frequency electric and magnetic fields (EMF) and/or the presence of high levels of light at night (LAN). EMF and LAN are said to reduce circulating levels of the hormone melatonin which, in turn, allows estrogen levels to rise and stimulate the turnover of breast epithelial stem cells and increase the risk for malignant transformation. Three laboratory-based studies, in which a total of 53 healthy young women were exposed at night to EMF or to LAN under controlled exposure conditions, were performed to determine whether such exposures reduce melatonin and are associated with further alterations in estrogen. All-night exposure to industrial-strength magnetic fields (60 Hz, 28.3 muT) had no effect on the blood levels of melatonin or estradiol. In contrast, nocturnal melatonin levels were profoundly suppressed, and the time of peak concentration was significantly delayed in women exposed to LAN, regardless of whether they were in the follicular or luteal phase of the menstrual cycle. These changes, however, were not associated with alterations in point-for-point matching measures of estradiol. Women who chronically secrete high or low amounts of melatonin each night (area-under-curve range: 86-1,296 pg/mL) also did not differ in their blood levels of estradiol. Taken together, these results are consistent with a growing body of evidence which generally suggests that environmental EMF exposure has little or no effect on the parameters measured in this report.