Negative ANCA in Wegener's granulomatosis
Negative ANCA in Wegener's granulomatosis
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韦格纳肉芽肿病 ANCA 阴性
DOI：
10.1017/s0022215100126969
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. G. Watson
中科院分区：
文献类型：
--
作者：
S. Carrie;K. Hughes;M. G. Watson
韦格纳肉芽肿病是一种以坏死性肉芽肿为特征的全身性血管炎，未经治疗预后较差。抗中性粒细胞胞浆抗体（ANCA）已被证明是一种有用的血清学标志物，可用于早期诊断和治疗这种疾病。我们报告两例患者谁是anca阴性的表现，尽管临床怀疑韦格纳肉芽肿病。在这两例患者中，随着疾病的进展，ANCA滴度呈阳性。
Abstract Wegener's granulomatosis is a systemic vasculitis characterized by necrotizing granulomata and without treatment is associated with a poor prognosis. Antineutrophil cytoplasmic antibodies (ANCA) have proved to be a useful serological marker allowing for early diagnosis and treatment of this condition. We report two cases of patients who were ANCA-negative on presentation despite clinical suspicion of Wegener's granulomatosis. In both cases the patients developed a positive ANCA titre as the disease progressed.