Uptake of catecholamines by human cardiac muscle in vitro.
Uptake of catecholamines by human cardiac muscle in vitro.
复制标题
体外人心肌对儿茶酚胺的摄取。
作者：
M. Petch;W. Nayler
对102例心脏手术患者的心肌去甲肾上腺素摄取进行了研究。右心房切片在含1.3×10~(-7)M~(-7)去甲肾上腺素的Krebs-Henseleit液中孵育。衰竭心肌的摄取较低，不仅通过增加孵育液中去甲肾上腺素的浓度，而且还可以通过添加药物去甲基米帕明、阿米替林和哇巴因来抑制。
Noradrenaline uptake was studied using heart muscle from 102 patients undergoing cardiac surgery. Slices of right atrium were incubated in Krebs-Henseleit solution containing 1.3 x 10(-7) M 3H-noradrenaline. Uptake was lower in failing heart muscle and was inhibited not only by increasing the noradrenaline concentration in the incubating medium but also by adding the drugs desmethylimipramine, amitryptyline, and ouabain.