Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms
Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms
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DOI：
10.1002/adfm.201901369
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发表时间：
2020-05-04
影响因子：
19
通讯作者：
Amdursky, Nadav
中科院分区：
文献类型：
--
作者：
Burnstine-Townley, Alex;Eshel, Yoni;Amdursky, Nadav
组织工程是一种很有前途的医学治疗方法，其目标是用在人造支架内生长的健康组织替换患病组织。由于心脏和脑相关疾病的高患病率，涉及一些组织坏死，心脏和神经元组织工程是再生医学中的热门研究领域。最近已经见证了使用导电支架用于这些组织的生长的增长趋势。虽然结果是无可辩驳的，但导电支架如何与电活性组织相互作用的机制仍然难以捉摸。报告了在该领域所做的所有工作的最新摘要，特别关注导电支架对形成的组织的性能的具体贡献。然后从电气工程的角度探讨了细胞-支架电子界面。讨论了该系统的电子结构和控制导电支架支持心脏和神经组织能力的机制和控制因素。使用几个模拟，所需的导电性的支架，以使它适合于组织工程，这也取决于性质的电荷载体也进行了讨论。
Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain-related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up-to-date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell-scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering-which also depends on the nature of the charge carriers-is also discussed.