Evidence for type III restriction and modification systems in Mycoplasma pulmonis
Evidence for type III restriction and modification systems in Mycoplasma pulmonis
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DOI：
10.1128/jb.01669-06
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Yu, Huilan
中科院分区：
文献类型：
--
作者：
Dybvig, Kevin;Cao, Z.;Yu, Huilan
肺支原体拥有一个基因盒，预计可编码 III 型限制和修饰 (R-M) 酶。转座子破坏预计编码该酶核酸内切酶亚基的基因，导致 R-M 活性丧失。基因组数据表明该盒是通过水平基因转移获得的并且可能位于移动元件上。
Mycoplasma pulmonis possesses a cassette of genes that are predicted to code for type III restriction and modification (R-M) enzymes. Transposon disruption of a gene predicted to code for the endonuclease subunit of the enzyme resulted in loss of R-M activity. Genomic data indicate that the cassette was acquired by horizontal gene transfer and possibly located on a mobile element.