Studies of the role of the central nucleus of the amygdala in controlling cardiovascular functions.
Studies of the role of the central nucleus of the amygdala in controlling cardiovascular functions.
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DOI：
10.1007/bf02463163
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发表时间：
2000-03-01
影响因子：
--
通讯作者：
Nikogosyan, T G
中科院分区：
文献类型：
--
作者：
Baklavadzhyan, O G;Pogosyan, N L;Nikogosyan, T G
用氯醛糖和戊巴比妥混合物麻醉猫，研究了高频刺激（100脉冲/秒）杏仁中央核对两条节后交感神经--心下神经和星状神经节椎分支生物电活动的影响，这两条交感神经分别支配冠状血管和前胸血管。杏仁核的中央被发现有差异，选择性的影响，在大多数实验中产生的综合活动的幅度增加，在下心神经和生物电位的幅度在椎神经减少。在一些实验中，这两个节后神经的活动的第二种类型的调制被认为是选择性抑制活动的心下神经和伴随的活动增加椎神经。杏仁核中央核的刺激引起全身动脉血压显着增加。本实验通过大鼠慢性实验，研究了杏仁中央核在实验性神经源性高血压形成中的作用;这些证实了对杏仁核中央核进行双侧电解损伤的大鼠防止了由每天施加压力诱导的神经源性高血压的发展，持续四周以诱导操作性厌恶条件反射，而对照组大鼠的情况并非如此。杏仁核中央核在血管张力调节中的作用进行了讨论。
Studies on cats anesthetized with a mixture of chloralose and Nembutal addressed the effects of high-frequency stimulation (100 impulses/sec) of the central nucleus of the amygdala on bioelectrical activity in two postganglionic sympathetic nerves-the inferior cardiac nerve and the vertebral branch of the stellate ganglion, which innervate the coronary vessels and the vessels of the anterior thorax respectively. The central nucleus of the amygdala was found to have differential, selective effects, in most experiments producing increases in the amplitude of integrated activity in the inferior cardiac nerve and decreases in the amplitude of biopotentials in the vertebral nerve. In a few experiments, a second type of modulation of the activities of these two postganglionic nerves was seen, with selective inhibition of activity in the inferior cardiac nerve and an accompanying increase in activity in the vertebral nerve. Stimulation of the central nucleus of the amygdala induced significant increases in systemic arterial blood pressure. The role of the central nucleus of the amygdala in the development of experimental neurogenic hypertension was studied in a series of chronic experiments on rats; these established that rats subjected to bilateral electrolytic lesioning of the central nucleus of the amygdala prevented the development of neurogenic hypertension induced by daily imposition of stress for four weeks for induction of operant aversive conditioned reflexes, which was not the case in control rats. The role of the central nucleus of the amygdala in the regulation of vascular tone is discussed.