WEIGHT GAIN FROM SIMPLE OVEREATING .2. SERUM LIPIDS AND BLOOD VOLUME
WEIGHT GAIN FROM SIMPLE OVEREATING .2. SERUM LIPIDS AND BLOOD VOLUME
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DOI：
10.1172/jci103413
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发表时间：
1957-01-01
影响因子：
15.9
通讯作者：
KEYS, A
中科院分区：
文献类型：
--
作者：
ANDERSON, JT;LAWLER, A;KEYS, A
二十名身体健康的精神分裂症男性在不改变身体活动的情况下增加了热量摄入。饮食在任何时候都基本恒定且蛋白质和维生素充足，额外的热量是通过在标准饮食中添加碳水化合物和少量（约额外热量的1/3）混合脂肪来提供的。因此，尽管来自脂肪的热量比例略有下降，但总脂肪摄入量有所增加。 20 周的平均卡路里增加范围为 8% 至 39%，体重增加从 2.5 公斤至 22.2 公斤，平均每周增加约 0.5 公斤。在暴饮暴食的前 5 周内，平均总血清胆固醇浓度上升 20 毫克/100 毫升，然后在接下来的 15 周内基本保持在同一水平，尽管体重继续以与前 5 周相同的速度增加。不同个体血清胆固醇浓度的升高往往与体重增加的速度成正比。在超速离心机中测量的血清中 Sf 12-20 脂蛋白组分的浓度在暴饮暴食的第 10 周至第 20 周期间趋于增加，尽管总血清胆固醇保持恒定。在暴饮暴食的最初几周内，体重增加往往与循环血浆和血容量的增加有关，此后没有进一步的变化。提出了关于胆固醇在脂肪运输中的作用的假设，该假设似乎可以解释高脂肪饮食和热量正平衡的营养过剩时血清胆固醇的增加；热量平衡期间或持续营养过剩的稳定状态下血清胆固醇的稳定性；当饮食热量和能量消耗同时增加时，血清胆固醇不会升高；以及低脂饮食和负热量平衡中血清胆固醇的降低。
Twenty physically healthy schizophrenic men increased their caloric intakes without changing their physical activity. The diet was substantially constant and fully adequate in proteins and vitamins at all times, the extra calories being provided by adding carbohydrates and a small amount (about 1/3 of the extra calories) of mixed fats to the standard diet. Thus the total fat intake increased though the proportion of calories from fats fell slightly. Average calorie increases for 20 weeks ranged from 8% to 39% and these produced weight gains from 2.5 to 22.2 kg, the average gain being about 0.5 kg/week. The average total serum cholesterol concentration rose 20 mg/100 ml during the first 5 weeks of overeating and then remained substantially constant at the same level during the next 15 weeks though weight gain continued at the same rate as during the first five weeks. The rise in serum cholesterol concentration in the various individuals tended to be proportional to the rate of weight gain. The concentration of the Sf 12-20 lipoprotein fraction in the serum, measured in the ultracentrifuge, tended to increase from the 10th to the 20th week of overeating though the total serum cholesterol remained constant. Weight gain tended to be associated with increase in circulating plasma and blood volume during the first weeks of overeating with no further change thereafter. A hypothesis as to the role of cholesterol in fat transport is presented which seems to explain the increase in serum cholesterol on a high fat diet and in over-nutrition with a positive calorie balance; the stability of the serum cholesterol during calorie equilibrium or in a steady state of continuing over-nutrition; the failure of serum cholesterol to rise when diet calories and energy expenditure are both increased in parallel; and the decrease in serum cholesterol on a low fat diet and in negative calorie balance.