The efficacy comparison of citalopram, fluoxetine, and placebo on motor recovery after ischemic stroke: a double-blind placebo-controlled randomized controlled trial
The efficacy comparison of citalopram, fluoxetine, and placebo on motor recovery after ischemic stroke: a double-blind placebo-controlled randomized controlled trial
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DOI：
10.1177/0269215518777791
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发表时间：
2018-08-01
影响因子：
3
通讯作者：
Karimialavijeh, Ehsan
中科院分区：
文献类型：
--
作者：
Asadollahi, Marjan;Ramezani, Mahtab;Karimialavijeh, Ehsan
目的：本研究旨在评估口服西酞普兰与氟西汀和安慰剂相比在卒中后运动障碍患者中的有效性。设计：在2015年1月至2016年1月期间进行了一项随机双盲安慰剂对照临床试验。设置：伊朗德黑兰一所大学附属城市医院的神经科。受试者：90名患有急性缺血性中风、偏瘫或轻偏瘫且Fugl-Meyer运动量表评分低于55分的成年患者被纳入研究。干预措施：参与者被随机分配到三组中的一组：A组口服氟西汀20 mg/d，B组口服西酞普兰20 mg/d，C组口服安慰剂，疗程均为90天。除了药物治疗外，所有参与者都接受了物理治疗。主要指标：90天时的功能状态，通过Fugl-Meyer运动量表评分进行测量。安慰剂、氟西汀和西酞普兰组的初始平均（SD）Fugl-Meyer运动量表评分为18.2（11.42）、20.08（14.53）和17.07（14.92）。90天后，安慰剂组的评分为27.96（18.71），氟西汀组为52.42（26.24），西酞普兰组为50.89（27.17）。与安慰剂组相比，氟西汀组和西酞普兰组Fugl-Meyer运动量表评分均显著提高（P=0.001）。结论：西酞普兰和氟西汀对缺血性脑卒中患者运动功能恢复的促进作用无显著性差异。然而，与安慰剂相比，两种药物都改善了中风后的运动功能。
Objective: The present study aimed to assess the effectiveness of oral citalopram, compared with fluoxetine and a placebo, in patients with post-stroke motor disabilities.Design: A randomized double-blind placebo-controlled clinical trial was conducted between January 2015 and January 2016.Setting: The neurology department of a university-affiliated urban hospital in Tehran, Iran.Subjects: Ninety adult patients with acute ischemic stroke, hemiplegia, or hemiparesis and a Fugl-Meyer Motor Scale score of below 55 were included.Interventions: Participants were randomly allocated to one of three groups: Group A received 20mg PO of fluoxetine daily, Group B received 20mg PO of citalopram daily, and Group C received a placebo PO The duration of the therapy was 90days. In addition to the medications, all of the participants received physiotherapy.Main measures: Functional status at 90days, which was measured by the Fugl-Meyer Motor Scale score.Results: The initial mean (SD) Fugl-Meyer Motor Scale scores for the placebo, fluoxetine, and citalopram groups were 18.2 (11.42), 20.08 (14.53), and 17.07 (14.92), respectively. After 90days, the scores were 27.96 (18.71) for the placebo group, 52.42 (26.24) for the fluoxetine group, and 50.89 (27.17) for the citalopram group. Compared with the placebo group, the mean Fugl-Meyer Motor Scale scores showed significant increases in the fluoxetine and citalopram groups (P=0.001).Conclusion: There was no significant difference between citalopram and fluoxetine in facilitating post-stroke motor recovery in ischemic stroke patients. However, compared with a placebo, both drugs improved post-stroke motor function.