Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects
Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects
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DOI：
10.1089/met.2018.0066
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发表时间：
2018-10-16
影响因子：
2.1
通讯作者：
Knop, Filip K.
中科院分区：
文献类型：
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作者：
Demant, Mia;Bagger, Jonatan I.;Knop, Filip K.
背景：空腹高胰高血糖素血症可能对2型糖尿病（T2D）患者的糖代谢有害，并可能导致肥胖和/或糖尿病前期患者的代谢紊乱。然而，空腹高胰高血糖素血症的机制仍然难以捉摸。方法：我们评估106例T2D患者（女性31%，年龄579岁）空腹高胰高血糖素血症与人口统计学和生化参数的相互关系[平均标准差，体重指数（BMI）： 30.1 +/- 4.4kg/m(2)；空腹血糖（FPG）： 9.61±2.39mM；血红蛋白A1c (HbA1c): 57.1 +/- 13.1mmol/mol]和163名非糖尿病对照组(29%为女性，年龄：45 +/- 17岁，BMI: 25.8 +/- 4.1kg/m(2)；FPG: 5.2 +/- 0.4mM；HbA1c: 35.4 +/- 3.8mmol/mol)。以空腹胰高血糖素为依赖参数，BMI、腰臀比（WHR）、血压、血红蛋白A1c、FPG、胰岛素浓度为独立参数，采用逐步回归方法进行多元线性回归分析。结果：t2dm患者空腹血浆胰高血糖素浓度显著高于t2dm患者(13.5 +/- 6.3 vs. 8.5 +/- 3.8mM， P
Background: Fasting hyperglucagonemia can be detrimental to glucose metabolism in patients with type 2 diabetes (T2D) and may contribute to metabolic disturbances in obese and/or prediabetic subjects. However, the mechanisms underlying fasting hyperglucagonemia remain elusive. Methods: We evaluated the interrelationship between fasting hyperglucagonemia and demographic and biochemical parameters in 106 patients with T2D (31% female, age: 579 years [meanstandard deviation; body mass index (BMI): 30.1 +/- 4.4kg/m(2); fasting plasma glucose (FPG): 9.61 +/- 2.39mM; hemoglobin A1c (HbA1c): 57.1 +/- 13.1mmol/mol] and 163 nondiabetic control subjects (29% female; age: 45 +/- 17 years; BMI: 25.8 +/- 4.1kg/m(2); FPG: 5.2 +/- 0.4mM; and HbA1c: 35.4 +/- 3.8mmol/mol). Multiple linear regression analysis was applied using a stepwise approach with fasting plasma glucagon as dependent parameter and BMI, waist-to-hip ratio (WHR), blood pressure, hemoglobin A1c, FPG, and insulin concentrations as independent parameters. Results: Fasting plasma glucagon concentrations were significantly higher among patients with T2D (13.5 +/- 6.3 vs. 8.5 +/- 3.8mM, P