Segregation analysis of mandibular prognathism in Libya
Segregation analysis of mandibular prognathism in Libya
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DOI：
10.1177/154405910308200707
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发表时间：
2003-07-01
影响因子：
7.6
通讯作者：
Marazita, ML
中科院分区：
文献类型：
--
作者：
El-Gheriani, AA;Maher, BS;Marazita, ML
下颌骨多突症的病因是多种遗传模式和环境因素共同作用的结果。遗传模式的变化可能部分是由于在各自的研究中使用了不同的统计方法。本研究的目的是调查的作用，遗传影响的病因，这一特点。我们对37个目前正在接受下颌骨多颌畸形治疗的患者家庭进行了分离分析。下颌骨多颌畸形被视为一个定性特征，头影测量X线片，牙科模型，并用于验证诊断照片。在整个数据集中的下颌骨的分离分析支持一个传递孟德尔的主要影响，与确定为最吝啬的遗传的主导模式。
The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to investigate the role of genetic influences in the etiology of this trait. We performed segregation analysis on 37 families of patients currently being treated for mandibular prognathism. Mandibular prognathism was treated as a qualitative trait, with cephalometric radiographs, dental models, and photographs used to verify diagnosis. Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious.