Mitochondria are sources of metabolic sink and arrhythmias.
Mitochondria are sources of metabolic sink and arrhythmias.
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DOI：
10.1016/j.pharmthera.2011.04.005
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发表时间：
2011-09
影响因子：
13.5
通讯作者：
O'Rourke, Brian
中科院分区：
文献类型：
--
作者：
Akar, Fadi G.;O'Rourke, Brian
线粒体在能量传递和细胞凋亡中起着重要作用。最近，世界各地多个实验室的广泛工作已经显着扩展了心肌线粒体的作用，从相对静态的细胞死亡和存活途径的仲裁者到高度动态的细胞器，形成跨心肌细胞的交互式功能网络。这些偶联的网络被证明通过调节强烈影响生理特性的细胞信号通路来强烈影响心肌细胞对氧化应激的反应。特别重要的是线粒体在调节心肌细胞中关键的电生理和钙循环特性中的作用，直接通过激活无数的线粒体离子通道或间接通过影响细胞信号传导级联、ATP水平和心肌细胞的整体氧化还原状态。这一重要的认识带来了新的兴趣，在更基本的水平上理解心脏代谢，特别是线粒体在健康和疾病中的确切作用。在这篇文章中，我们提供了一个概述的最新进展，我们越来越多地了解的基本作用，心脏线粒体在致命性心律失常的发生。
Mitochondria have long been recognized for their central role in energy transduction and apoptosis. More recently, extensive work in multiple laboratories around the world has significantly extended the role of cardiac mitochondria from relatively static arbitrators of cell death and survival pathways to highly dynamic organelles that form interactive functional networks across cardiomyocytes. These coupled networks were shown to strongly affect cardiomyoyte responses to oxidative stress by modulating cell signaling pathways that strongly impact physiological properties. Of particular importance is the role of mitochondria in modulating key electrophysiological and calcium cycling properties in cardiomyocytes, either directly through activation of a myriad of mitochondrial ion channels or indirectly by affecting cell signaling cascades, ATP levels, and the over-all redox state of the cardiomyocyte. This important recognition has ushered a renewed interest in understanding, at a more fundamental level, the exact role that cardiac metabolism, in general and mitochondria, in particular, play in both health and disease. In this article, we provide an overview of recent advances in our growing understanding of the fundamental role that cardiac mitochondria play in the genesis of lethal arrhythmias.
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DOI：
10.1016/j.biocel.2009.02.016
发表时间：
2009-10
影响因子：
4
作者：
Aon, M. A.;Cortassa, S.;Akar, F. G.;Brown, D. A.;Zhou, L.;O'Rourke, B.
通讯作者：
O'Rourke, B.
谷胱甘肽氧化诱导的心律不齐可以通过预防线粒体去极化来抑制。
影响因子：
5
作者：
Brown, David A.;Aon, Miguel A.;Frasier, Chad R.;Sloan, Ruben C.;Maloney, Andrew H.;Anderson, Ethan J.;O'Rourke, Brian
通讯作者：
O'Rourke, Brian
DOI：
10.1152/ajpheart.00359.2007
发表时间：
2007-10-01
影响因子：
4.8
作者：
Chen, Fuhua;De Diego, Carlos;Weiss, James N.
通讯作者：
Weiss, James N.
影响因子：
4.8
作者：
Aon, Miguel A.;Cortassa, Sonia;O'Rourke, Brian
通讯作者：
O'Rourke, Brian
影响因子：
3.4
作者：
Brady, NR;Elmore, SP;Westerhoff, HV
通讯作者：
Westerhoff, HV