Genetics of clindamycin resistance in Bacteroides.
Genetics of clindamycin resistance in Bacteroides.
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拟杆菌中克林霉素耐药性的遗传学。
DOI：
10.1007/978-1-4613-2447-8_39
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Macrina,FL
中科院分区：
文献类型：
--
作者：
Smith,CJ;Liechty,MC;Rasmussen,JL;Macrina,FL
在人类肠道菌群中，结肠类杆菌属的数量占优势（2，6）。除了作为土著植物群存在外，这些微生物还是与各种感染过程有关的重要机会致病菌（1）。克林霉素是一种林可酰胺类抗生素，被广泛用作治疗类杆菌引起的厌氧菌感染的一线药物。然而，林可酰胺-大环内酯（LM）（例如，临床环境中的类杆菌（18）严重损害了常规的抗微生物化疗。
The colonicBacteroidesspecies are numerically predominant members of the human intestinal tract microflora (2,6). In addition to their presence as indigenous flora, these organisms are significant opportunistic pathogens implicated in a variety of infectious processes (1). Clindamycin, a lincosamide antibiotic, is used extensively as a first line drug for the treatment of anaerobic infections caused byBacteroidesspecies. However, the increasing emergence of lincosamide-macrolide (LM) (e.g., clindamycin-erythromycin) resistantBacteroidesin the clinical setting (18) has severely compromised routine antimicrobial chemotherapy.