Plasma 25-Hydroxyvitamin D Is Associated with Markers of the Insulin Resistant Phenotype in Nondiabetic Adults
Plasma 25-Hydroxyvitamin D Is Associated with Markers of the Insulin Resistant Phenotype in Nondiabetic Adults
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DOI：
10.3945/jn.108.093831
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发表时间：
2009-02-01
影响因子：
4.2
通讯作者：
Jacques, Paul F.
中科院分区：
文献类型：
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作者：
Liu, Enju;Meigs, James B.;Jacques, Paul F.
我们研究了血浆25-羟基维生素D [25（OH）D]和胰岛素抵抗表型标志物之间的横截面关联。血浆25（OH）D浓度测定808例非糖尿病参与者的Frachial Offspring研究。结果测量包括空腹和75 g口服葡萄糖耐量试验（OGTT）后2小时的葡萄糖和胰岛素;这些用于计算稳态模型评估-胰岛素抵抗（HOMA-IR）和胰岛素敏感性指数（ISI0.120）。我们还测量了血浆脂联素、三酰甘油和HDL胆固醇浓度作为胰岛素抵抗表型的标志物。在调整了年龄、性别、BMI、腰围和当前吸烟状况后，血浆25（OH）D浓度与空腹血糖和胰岛素浓度以及HOMA-IR呈负相关。与血浆25（OH）D最低三分位数类别的参与者相比，最高三分位数组的空腹血糖浓度降低1.6%（P趋势= 0.007），空腹胰岛素浓度降低9.8%（P趋势=0.001），HOMA-IR评分降低12.7%（P趋势< 0.001）。校正年龄和性别后，血浆25（OH）D与ISI 0，120，血浆脂联素和HDL胆固醇呈正相关，与血浆甘油三酯呈负相关，但进一步校正BMI，腰围和当前吸烟状况后，这些相关性不再显著。25（OH）D和OGTT后2小时血糖不相关。在无糖尿病的成年人中，维生素D状况与胰岛素抵抗的替代空腹指标呈负相关。这些结果表明，维生素D状态可能是2型糖尿病的一个重要决定因素。J.营养139：329-334，2009.
We examined the cross-sectional association between plasma 25-hydroxyvitamin D [25(OH)D] and markers of the insulin resistant phenotype. Plasma 25(OH)D concentrations were measured in 808 nondiabetic participants of the Framingham Offspring Study. Outcome measures included fasting and 2-h post 75-g oral glucose tolerance test (OGTT) glucose and insulin; these were used to calculate the homeostatic model assessment-insulin resistance (HOMA-IR) and insulin sensitivity index (ISI0.120). We also measured plasma adiponectin, triacylglycerol, and HDL cholesterol concentrations as markers of the insulin-resistant phenotype, After adjusting for age, sex, BMI, waist circumference, and current smoking status, plasma 25(OH)D concentration was inversely associated with fasting plasma glucose and insulin concentrations, and HOMA-IR. Compared with the participants in the lowest tertile category of plasma 25(OH)D, those in the highest tertile category had a 1.6% lower concentration of fasting plasma glucose (P-trend = 0.007), 9.8% lower concentration of fasting plasma insulin (P-trend=0.001), and 12.7% lower HOMA-IR score (P-trend < 0.001). After adjusting for age and sex, plasma 25(OH)D was positively associated with ISI0,120, plasma adiponectin, and HDL cholesterol and inversely associated with plasma triacylglycerol, but these associations were no longer significant after further adjustment for BMI, waist circumference, and current smoking status. 25(OH)D and 2-h post-OGTT glucose were not associated. Among adults without diabetes, vitamin D status was inversely associated with surrogate fasting measures of insulin resistance. These results suggest that vitamin D status may be an important determinant for type 2 diabetes mellitus. J. Nutr. 139: 329-334, 2009.