Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy
Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy
复制标题
DOI：
10.1080/21691401.2018.1434185
复制
发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Jin, Liang
中科院分区：
文献类型：
--
作者：
Cao, Shunxiu;Guo, Jiamin;Jin, Liang
抗癌药物的主要挑战是肿瘤靶向性差。目前，细胞载体被广泛研究用于递送抗癌剂。人脐带间充质干细胞（human umbilical cord derived mesenchymal stem cells，hUC-MSCs）是一种理想的细胞候选细胞，具有天然的肿瘤趋化性。在此，我们构建了携带含有阿霉素的转铁蛋白激发的纳米颗粒（hUC-MSCs-Tf-inspired-NPs）的hUC-MSCs，以实现增强的抗肿瘤功效，并进行了评价。结果表明，hUC-MSCs-Tf-inspired-NPs不仅具有Tf-inspired-NPs的控释特性，而且融合了MSCs的肿瘤嗜性和穿透能力。用hUC-MSC-Tf激发的NPs治疗的携带乳腺癌MCF-7的裸鼠的肿瘤体积与用游离药物或Tf激发的NPs治疗的那些相比显著减小。因此，负载Tf激发的NPs的hUC-MSC具有递送抗癌药物的潜力。
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.