Reduced brain activation in violent adolescents during response inhibition.
Reduced brain activation in violent adolescents during response inhibition.
复制标题
反应抑制期间暴力青少年的大脑激活减少
DOI：
10.1038/srep21318
复制
发表时间：
2016-02-18
影响因子：
4.6
通讯作者：
Shao Y
中科院分区：
文献类型：
--
作者：
Qiao Y;Mei Y;Du X;Xie B;Shao Y
抑制性控制的缺陷与攻击性和暴力行为有关。本研究旨在观察暴力青少年在反应抑制过程中是否表现出不同的脑激活模式，并确定这些脑区所起的作用。采用自评法和改良的公开攻击量表(MOAS)对暴力行为进行评定。对22名暴力青少年和17名年龄在12-18岁的健康志愿者进行了功能磁共振成像。在扫描时，执行了进行/不进行任务。组间比较显示，与对照组相比，暴力组大鼠双侧颞中上回、海马区和右侧眶前区(BA11)的激活显著减少。同时，暴力组的前额叶皮质比对照组有更广泛的激活。暴力组前额叶皮质激活广泛，但缺乏焦点，在反应抑制时未能在一些功能相关的区域产生强烈的激活。
Deficits in inhibitory control have been linked to aggression and violent behaviour. This study aimed to observe whether violent adolescents show different brain activation patterns during response inhibition and to ascertain the roles these brain regions play. A self-report method and modified overt aggression scale (MOAS) were used to evaluate violent behaviour. Functional magnetic resonance imaging was performed in 22 violent adolescents and 17 matched healthy subjects aged 12 to 18 years. While scanning, a go/no-go task was performed. Between-group comparisons revealed that activation in the bilateral middle and superior temporal gyrus, hippocampus, and right orbitofrontal area (BA11) regions were significantly reduced in the violent group compared with the control group. Meanwhile, the violent group had more widespread activation in the prefrontal cortex than that observed in the control group. Activation of the prefrontal cortex in the violent group was widespread but lacking in focus, failing to produce intensive activation in some functionally related regions during response inhibition.