General and abdominal obesity and incident hypertension among people living with HIV on antiretroviral therapy
General and abdominal obesity and incident hypertension among people living with HIV on antiretroviral therapy
复制标题
接受抗逆转录病毒治疗的艾滋病毒感染者的全身肥胖和腹部肥胖以及高血压事件
DOI：
10.1080/09540121.2020.1852158
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发表时间：
2020-12-02
影响因子：
1.7
通讯作者：
Ding，Yingying
中科院分区：
文献类型：
--
作者：
Xu，Xiaohui;Chen，Xiaoxiao;Ding，Yingying
摘要高血压在人类免疫缺陷病毒(HIV)感染者中高度流行。我们试图通过抗逆转录病毒治疗来表征PLWH中高血压的发病率，重点关注在随访期间全身改变和腹型肥胖对高血压的影响。这是一项前瞻性分析，研究对象为229名接受治疗的40岁以上无高血压的PLWH患者。总体而言，中位随访时间为2.9年，26.2%的PLWH发展为高血压。在多变量模型中，与那些在基线和随访时都没有测量肥胖的人相比，PLWH在两个场合(调整后的优势比[AOR] = 3.83，P = 0.006)或仅在基线(AOR = 5.45，P = 0.003)、在两个场合(AOR = 3.87，P = 0.001)或仅在随访(AOR = 2.27；在两种情况下腹型肥胖(以腰臀比衡量)(AOR = 2.27，P = 0.077)均增加发生高血压的风险。我们的数据显示，在接受治疗的PLWH患者中，一般肥胖和腹型肥胖都会增加高血压风险，尤其是持续性肥胖。
ABSTRACT Hypertension is highly prevalent among people living with HIV (PLWH). We sought to characterize the hypertension incidence among PLWH on antiretroviral therapy, focusing on the effect of change in general and abdominal obesity on hypertension during follow-up. This was a prospective analysis of 229 treated PLWH aged over 40 years without hypertension at baseline. Overall a median follow-up of 2.9 years, 26.2% PLWH developed hypertension. In multivariable models, compared to those without obesity measures at both baseline and follow-up visit, PLWH with general obesity at both occasions (adjusted odds ratio [aOR] = 3.83, P = 0.006) or at baseline only (aOR = 5.45, P = 0.003), abdominal obesity (measured as waist circumference) at both occasions (aOR = 3.87, P = 0.001) or at follow-up only (aOR = 2.27; 9P = 0.060), abdominal obesity (measured as waist-to-hip ratio) at both occasions (aOR = 2.27, P = 0.077) were at increased risk of incident hypertension. Our data show that both general and abdominal obesity especially in the persistent status increase the hypertension risk in treated PLWH.