Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension
复制标题
肾多巴胺受体和氧化应激：在高血压中的作用
DOI：
10.1089/ars.2020.8106
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发表时间：
2020-05-29
影响因子：
6.6
通讯作者：
Zeng, Chunyu
中科院分区：
文献类型：
--
作者：
Yang, Jian;Villar, Van Anthony M.;Zeng, Chunyu
意义：肾脏在长期控制血压中起着重要作用。氧化应激是高血压发生发展的基本机制之一。多巴胺通过5种受体亚型在血压控制中发挥重要作用，包括抑制氧化应激，研究进展：多巴胺受体通过调节肾脏的氧化应激，维持正常的钠平衡和血压稳态。这种调节的异常可能参与高血压的发病机制。关键问题：本文综述了氧化应激和肾内多巴胺能系统在血压调节中的重要作用，总结了肾脏多巴胺受体介导的抗氧化作用的研究现状，包括减少活性氧的产生，抑制氧化剂烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶，并讨论了其潜在的机制，包括G蛋白偶联受体激酶4（GRK4）活性的增加和高血压状态下肾脏多巴胺受体的异常运输。未来方向：确定肾脏多巴胺受体在氧化应激调节中的机制及其在高血压发病机制中的作用仍然是一个重要的研究热点。随着对肾脏多巴胺受体与氧化应激相互调节在血压调节中作用的深入了解，可能为高血压的发病机制提供新的认识，并为高血压的治疗提供新的策略。
Significance: The kidney plays an important role in the long-term control of blood pressure. Oxidative stress is one of the fundamental mechanisms responsible for the development of hypertension. Dopamine, via five subtypes of receptors, plays an important role in the control of blood pressure by various mechanisms, including the inhibition of oxidative stress.Recent Advances: Dopamine receptors exert their regulatory function to decrease the oxidative stress in the kidney and ultimately maintain normal sodium balance and blood pressure homeostasis. An aberration of this regulation may be involved in the pathogenesis of hypertension.Critical Issues: Our present article reviews the important role of oxidative stress and intrarenal dopaminergic system in the regulation of blood pressure, summarizes the current knowledge on renal dopamine receptor-mediated antioxidation, including decreasing reactive oxygen species production, inhibiting pro-oxidant enzyme nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, and stimulating antioxidative enzymes, and also discusses its underlying mechanisms, including the increased activity of G protein-coupled receptor kinase 4 (GRK4) and abnormal trafficking of renal dopamine receptors in hypertensive status.Future Directions: Identifying the mechanisms of renal dopamine receptors in the regulation of oxidative stress and their contribution to the pathogenesis of hypertension remains an important research focus. Increased understanding of the role of reciprocal regulation between renal dopamine receptors and oxidative stress in the regulation of blood pressure may give us novel insights into the pathogenesis of hypertension and provide a new treatment strategy for hypertension.