Synthesis of Spirofluorenyl-beta-Lactams through Cycloaddition and Ring Contraction from N-Aryl Fluorenone Nitrones and Methylenecyclopropanes
Synthesis of Spirofluorenyl-beta-Lactams through Cycloaddition and Ring Contraction from N-Aryl Fluorenone Nitrones and Methylenecyclopropanes
复制标题
N-芳基芴酮硝酮和亚甲基环丙烷通过环加成和缩环合成螺芴基-β-内酰胺
DOI：
10.1002/adsc.201900523
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发表时间：
2019
影响因子：
5.4
通讯作者：
Mo Dong-Liang
中科院分区：
文献类型：
--
作者：
Wei Cui;Zhu Jie-Feng;Zhang Jin-Qi;Deng Qi;Mo Dong-Liang
A variety of spirofluorenyl‐β‐lactams have been prepared in moderate yields over three steps fromN‐aryl fluorenone nitrones and methylenecyclopropanes through a [3+2] cycloaddition, reduction and subsequent acid‐catalyzed ring contraction cascade strategy under mild reaction conditions. Experimental studies showed that the stereochemistry remained intact after the ring contraction step. Furthermore, the obtained spirofluorenyl‐β‐lactam was easily converted to two novel spiroazetidine and spiroquinolinone scaffolds in good yields.
