5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex.
5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex.
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5-羟色胺 1a 受体激动剂可阻断声惊跳反射的前脉冲抑制。
DOI：
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发表时间：
1992
影响因子：
3.5
通讯作者：
J. K. Weatherspoon
中科院分区：
文献类型：
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作者：
G. Rigdon;J. K. Weatherspoon
在哺乳动物中，在引起惊吓的听觉刺激（脉冲）前100毫秒出现非惊吓刺激（前脉冲）会降低惊吓反射的幅度。精神分裂症患者的声惊吓反射的前脉冲抑制比非精神分裂症患者小，这种现象被假设为反映了精神分裂症精神病的感觉运动门控缺陷。本实验观察了5种5-羟色胺1a（5-HT 1a，serotonin）受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OHDPAT）、5-甲氧基二甲基色胺、丁螺环酮、吉哌隆和伊沙匹隆对大鼠前脉冲抑制和惊吓反射幅度的影响。所有五种药物在对惊吓反射幅度或运动活动没有影响的剂量下均降低前脉冲抑制。8-OHDPAT对前脉冲抑制的减少可被5-HT 1a受体拮抗剂（-）普萘洛尔拮抗，部分可被多巴胺D2受体拮抗剂氟哌啶醇拮抗，但不被5-HT 2受体拮抗剂酮色林或麦角新碱拮抗。8-在利血平或丁苯那嗪预处理以消耗神经元胺的受试者中，OHDPAT没有减少前脉冲抑制，但是对该结果的解释是复杂的，因为单独给予利血平和丁苯那嗪减少了前脉冲抑制。结果表明，5-HT 1a受体激动剂阻断声惊吓反射的前脉冲抑制，可能通过多巴胺能机制。
Presentation of a nonstartling stimulus (prepulse) 100 msec before a startle-eliciting auditory stimulus (pulse) reduces startle reflex amplitude in mammals. Prepulse inhibition of acoustic startle reflex is smaller in schizophrenics than in nonschizophrenics, a phenomenon that has been hypothesized to reflect sensorimotor gating deficits underlying schizophrenic psychosis. Five 5-hydroxytryptamine1a (5-HT1a, serotonin) receptor agonists: 8-hydroxy-2-(di-n-propylamino) tetraline (8-OHDPAT), 5-methoxydimethyltryptamine, buspirone, gepirone and ipsapirone, were tested for effects on prepulse inhibition and startle reflex amplitude in rats. All five agents reduced prepulse inhibition at doses that had no effect on startle reflex amplitude or motor activity. Reduction of prepulse inhibition by 8-OHDPAT was antagonized by (-)propranolol, a 5-HT1a receptor antagonist, and partially by haloperidol, a dopamine D2 receptor antagonist, but not by ketanserin or methysergide, 5-HT2 receptor antagonists. 8-OHDPAT did not reduce prepulse inhibition in subjects pretreated with reserpine or tetrabenazine to deplete neuronal amines, but interpretation of this result is complicated because reserpine and tetrabenazine given alone reduced prepulse inhibition. The results indicate that 5-HT1a receptor agonists block prepulse inhibition of acoustic startle reflex, possibly via dopaminergic mechanisms.