Influence of subcutaneous adipose tissue mass on dermal elasticity and sagging severity in lower cheek
Influence of subcutaneous adipose tissue mass on dermal elasticity and sagging severity in lower cheek
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DOI：
10.1111/j.1600-0846.2010.00438.x
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发表时间：
2010-08-01
影响因子：
2.2
通讯作者：
Amano, Satoshi
中科院分区：
文献类型：
--
作者：
Ezure, Tomonobu;Amano, Satoshi
皮下脂肪组织位于真皮层之下，但两者之间的相互作用还不清楚。最近，我们在肥胖啮齿动物模型中发现皮下脂肪层影响皮肤性质，目的探讨皮下脂肪层对人类皮肤性质和形态的影响，方法采用Prosound alpha 5（R）超声测量皮下脂肪质量，采用在体抽吸皮肤弹性仪测量皮肤弹性（Cutometer MPA 580（R）），并在70名日本女性志愿者（年龄; 31-59，BMI; 17.1-36.2）的下脸颊处使用基于BMI的分级标准从形态学上评估下垂严重程度。结果皮下脂肪层厚度与皮肤弹性参数呈显著负相关，弹性变形、弹性变形恢复、延展性、总变形恢复、粘弹性与弹性扩张的比率和总弹性，包括蠕变和蠕变恢复。此外，我们研究了它们对面部形态的影响，如下垂。皮下脂肪量与面颊下垂程度呈显著正相关（R=0.442，P < 0.001），皮肤弹性与面颊下垂程度呈显著负相关（R=-0.358，P < 0.01）。
BackgroundSubcutaneous adipose tissue lies just beneath the dermal layer, but the interaction between the two is not well understood. Recently, we showed that the subcutaneous adipose layer affects dermal properties in an obese rodent model.ObjectiveTo explore the influence of the subcutaneous adipose layer on dermal properties and morphology in humans.MethodsSubcutaneous adipose mass was measured by ultrasound using a Prosound alpha 5 (R), dermal elasticity was measured using an in vivo suction skin elasticity meter (Cutometer MPA 580 (R)), and sagging severity were evaluated morphologically using photograph-based grading criteria at the lower cheek in 70 Japanese female volunteers (age; 31-59, BMI; 17.1-36.2). The correlations among the results were examined.ResultsThickness of the subcutaneous adipose layer was significantly and negatively correlated with dermal elasticity parameters, i.e., elastic deformation, elastic deformation recovery, extensibility, total deformation recovery, ratio of viscoelasticity to elastic distention and overall elasticity, including creep and creep recovery. Furthermore, we investigated their influence on facial morphology, such as sagging. The subcutaneous adipose mass was significantly and positively correlated with sagging severity at the lower cheek (R=0.442, P < 0.001), and there was a significant negative correlation between dermal elasticity and sagging severity (R=-0.358, P < 0.01).ConclusionThese results indicate that increment of subcutaneous adipose mass impairs dermal elasticity, which in turn exacerbates sagging severity.