Taurine Recovers Testicular Steroidogenesis and Spermatogenesis in Streptozotocin-Induced Diabetic Rats
Taurine Recovers Testicular Steroidogenesis and Spermatogenesis in Streptozotocin-Induced Diabetic Rats
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DOI：
10.1007/978-94-024-1079-2_62
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Yang, Jiancheng
中科院分区：
文献类型：
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作者：
Liu, Hong;Lin, Shumei;Yang, Jiancheng
大量研究证实，糖尿病男性生殖障碍与胰岛素缺乏和高血糖引起的氧化应激导致的睾丸类固醇生成和精子生成功能障碍有关。已发现牛磺酸通过其类胰岛素和胰岛细胞保护活性对糖尿病和糖尿病影响有益。此外，我们前期的研究发现，牛磺酸可以增强睾丸的抗氧化能力，刺激下丘脑-垂体-睾丸轴的内分泌活动，提高睾酮水平，提高精子质量，抑制睾丸功能的恶化。因此，我们假设牛磺酸可能对糖尿病状态下的睾丸功能障碍具有有益作用。在这里，我们研究了牛磺酸对链脲佐菌素 (STZ) 诱导的 I 型糖尿病大鼠睾丸类固醇生成和精子发生的影响。我们观察到牛磺酸治疗可以显着增加糖尿病大鼠的体重和睾丸重量、睾丸SDH和G6PDH活性、降低血清空腹血糖浓度。牛磺酸给药也明显提高血清GnRH、LH、FSH、T含量以及睾丸StAR、3β-HSD、17β-HSD mRNA表达水平，表明牛磺酸可以改善糖尿病动物睾丸类固醇生成。最后，我们发现补充牛磺酸能有效提高精子数量和活力，减少精子异常，提示牛磺酸可以增强糖尿病大鼠睾丸的生精功能。总之，目前的数据表明，牛磺酸可能通过增加下丘脑-垂体-睾丸轴的内分泌活性来挽救STZ诱导的I型糖尿病大鼠睾丸类固醇生成和精子发生的功能。
A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine is profitable for diabetes mellitus and diabetic implications through its insulin-like and islet cells protective activity. Furthermore, our previous studies found that taurine could increase testicular anti-oxidative ability, stimulate the endocrine activity of hypothalamic-pituitary-testicular axis, elevate testosterone level, raise sperm quality, suppress the deterioration of testicular function. Accordingly, we hypothesized that taurine may have beneficial effects on testicular dysfunction under diabetic mellitus status. Here, we investigated the effects of taurine on testicular steroidogenesis and spermatogenesis in streptozotocin (STZ)-induced type I diabetic rats. We observed that taurine treatment can markedly increase the body and testis weights, testicular SDH and G6PDH activities, decrease the serum fasting glucose concentration of diabetic rats. Serum contents of GnRH, LH, FSH, T, and testicular StAR, 3 beta-HSD, 17 beta-HSD mRNA expression levels were also obviously raised by taurine administration, indicating that taurine can improve testicular steroidogenesis in diabetic animals. Finally, we found taurine supplementation effectively elevated the sperm count and motility, reduced sperm abnormality, suggesting that taurine can increase the testicular spermatogenesis function of diabetic rat. In summary, the present data indicated that taurine can rescue the function of testicular steroidogenesis and spermatogenesis in STZ-induced type I diabetic rats possibly by increasing the endocrine activity of hypothalamic-pituitary-testicular axis.