Isolated cutaneous anaplastic large cell lymphoma progressing to severe systemic disease with myocardial involvement and central nervous system infiltration
Isolated cutaneous anaplastic large cell lymphoma progressing to severe systemic disease with myocardial involvement and central nervous system infiltration
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DOI：
10.1002/pbc.21357
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发表时间：
2008-04-01
影响因子：
3.2
通讯作者：
Pizer, Barry
中科院分区：
文献类型：
--
作者：
Rannan-Eliya, Yi Fan;Pulford, Karen;Pizer, Barry
间变性大细胞淋巴瘤（ALCL）是一种罕见的肿瘤，约占儿童淋巴瘤的10-15%。我们描述的情况下，女性谁最初提出了局部皮肤病与昆虫叮咬有关。然而，随后，她复发了广泛的系统性alk阳性ALCL，包括心肌淋巴瘤沉积，这是一种非常罕见的表现。她的疾病对化疗反应良好，但她后来在中枢神经系统复发。我们还提供了对ALK免疫反应的数据，显示循环中ALK抗体水平的波动对应于她疾病的不同阶段。
Anaplastic large cell lymphoma (ALCL) is a rare tumor comprising around 10-15% of childhood lymphomas. We describe the case of a female who initially presented with localized skin disease associated with an insect bite. However, she Subsequently relapsed with widespread systemic ALK-positive ALCL that included lymphoma deposits in the myocardium, a very rare manifestation. Her disease responded well to chemotherapy but she later developed a fatal relapse in the CNS. We also present data on an immune response to ALK, demonstrating a fluctuation in the levels of circulating antibodies to ALK corresponding to the different phases of her illness.