A genomic strategy to elucidate modules of oncogenic pathway signaling networks.
A genomic strategy to elucidate modules of oncogenic pathway signaling networks.
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阐明致癌途径信号网络模块的基因组策略。
DOI：
10.1016/j.molcel.2009.02.030
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发表时间：
2009-04-10
期刊：
影响因子：
16
通讯作者：
Nevins, Joseph R.
中科院分区：
文献类型：
--
作者：
Chang, Jeffrey T.;Carvalho, Carlos;Mori, Seiichi;Bild, Andrea H.;Gatza, Michael L.;Wang, Quanli;Lucas, Joseph E.;Potti, Anil;Febbo, Phillip G.;West, Mike;Nevins, Joseph R.
最近的研究强调了途径特异性解释对于理解人类癌症中基因改变的功能相关性的重要性。虽然信号活动通常被概念化为线性事件，但实际上它们反映了由每个模块响应输入信号组装而成的复杂功能网络的活动。为了更深入地了解这种网络结构，我们开发了一种方法，将通路解构为由基因表达特征表示的模块。我们的研究证实，它们代表了与已知生化途径结构相关的潜在生物活性单位。重要的是，我们发现这些信号模块提供了工具来剖析定义疾病结果的致癌状态的复杂性以及对特定途径治疗的反应。我们建议，这个模型的通路结构构成了一个框架，研究信息传播通过细胞网络的过程，并阐明基本模块的细胞和临床表型的关系。
Recent studies have emphasized the importance of pathway-specific interpretations for understanding the functional relevance of gene alterations in human cancers. Although signaling activities are often conceptualized as linear events, in reality they reflect the activity of complex functional networks assembled from modules that each respond to input signals. To acquire a deeper understand of this network structure, we developed an approach to deconstruct pathways into modules represented by gene expression signatures. Our studies confirm that they represent units of underlying biological activity linked to known biochemical pathway structures. Importantly, we show that these signaling modules provide tools to dissect the complexity of oncogenic states that define disease outcomes as well as response to pathway-specific therapeutics. We propose that this model of pathway structure constitutes a framework to study the processes by which information propogates through cellular networks, and to elucidate the relationships of fundamental modules to cellular and clinical phenotypes.
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宇宙（癌症中的体细胞突变目录）数据库和网站。
影响因子：
8.8
作者：
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R
通讯作者：
Wooster, R
DOI：
10.1111/j.1600-0749.2006.00322.x
发表时间：
2006-08-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Hoek, Keith S.;Schlegel, Natalie C.;Dummer, Reinhard
通讯作者：
Dummer, Reinhard
影响因子：
5.3
作者：
Ishida, S;Huang, E;Nevins, JR
通讯作者：
Nevins, JR
影响因子：
45.3
作者：
Khambata-Ford, Shirin;Garrett, Christopher R.;Mauro, David J.
通讯作者：
Mauro, David J.
DOI：
10.1126/science.1164382
发表时间：
2008-09-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Parsons DW;Jones S;Zhang X;Lin JC;Leary RJ;Angenendt P;Mankoo P;Carter H;Siu IM;Gallia GL;Olivi A;McLendon R;Rasheed BA;Keir S;Nikolskaya T;Nikolsky Y;Busam DA;Tekleab H;Diaz LA Jr;Hartigan J;Smith DR;Strausberg RL;Marie SK;Shinjo SM;Yan H;Riggins GJ;Bigner DD;Karchin R;Papadopoulos N;Parmigiani G;Vogelstein B;Velculescu VE;Kinzler KW
通讯作者：
Kinzler KW