Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone
Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone
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DOI：
10.1359/jbmr.071009
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发表时间：
2008-02-01
影响因子：
6.2
通讯作者：
Guo, X. Edward
中科院分区：
文献类型：
--
作者：
Liu, X. Sherry;Sajda, Paul;Guo, X. Edward
小梁板和棒是决定小梁骨力学性能的重要微结构特征。一个完整的体积分解的单个小梁板和棒被用来评估方向和形态的71人小梁骨样本。基于its的形态学分析可以更好地表征微结构，并有助于预测小梁骨的各向异性力学性能。小梁结构的标准形态学分析缺乏单个小梁板和棒的明确分割。在本研究中，开发了一种完整的体积分解技术，将小梁骨微观结构分割为单个板和棒。研究了骨小梁型相关形态学参数对骨小梁各向异性弹性模量的影响。材料和方法：对71例股骨颈、胫骨和椎体骨小梁标本进行CT或连续铣削成像。采用完全体积分解法将骨小梁微观结构分割成单个板和棒。确定每个小梁的方向，轴向骨体积分数（aBV/TV），沿各向异性轴向排列的骨体积分数，与弹性模量相关。导出了与显微结构类型相关的形态学参数，并与标准形态学参数进行了比较。通过有限元分析（FEA）对各向异性弹性模量的贡献进行了评价和比较。结果：小梁取向的分布表明，纵板和横棒在所有三个解剖部位占主导地位。总体而言，各轴aBV/TV与轴向弹性模量的相关性（r(2) = 0.95，近似于0.99）优于BV/TV （r(2) = 0.93，近似于0.94）。板相关形态学参数与相应的标准形态学参数的相关性一般高于杆相关形态学参数。基于单个小梁分割（ITS）形态学参数的六个弹性模量的多元线性回归模型（调整r(2) = 0.95，类似于0.98）与使用标准形态学参数的模型（调整r(2) = 0.94，类似于0.97）表现一样好，但揭示了单个小梁板或棒的特定贡献。结论：基于its的形态学分析可以更好地表征小梁骨的形态和小梁方向。骨小梁的轴向载荷主要由骨小梁的轴向排列量来维持。结果表明，骨小梁钢板对骨小梁的整体弹性性能起主导作用。
Trabecular plates and rods are important microarchitectural features in determining mechanical properties of trabecular bone. A complete volumetric decomposition of individual trabecular plates and rods was used to assess the orientation and morphology of 71 human trabecular bone samples. The ITS-based 14 morphological analyses better characterize microarchitecture and help predict anisotropic mechanical properties of trabecular bone.Introduction: Standard morphological analyses of trabecular architecture lack explicit segmentations of individual vidual trabecular plates and rods. In this study, a complete volumetric decomposition technique was developed to segment trabecular bone microstructure into individual plates and rods. Contributions of trabecular type- associated morphological parameters to the anisotropic elastic moduli of trabecular bone were studied.Materials and Methods: Seventy-one human trabecular bone samples from the femoral neck (FN), tibia, and vertebral body (VB) were imaged using mu CT or serial milling. Complete volumetric decomposition was applied to segment trabecular bone microstructure into individual plates and rods. The orientation of each individual trabecula was determined, and the axial bone volume fractions (aBV/TV), axially aligned bone volume fraction along each orthotropic axis, were correlated with the elastic moduli. The microstructural type-associated morphological parameters were derived and compared with standard morphological parameters. Their contributions to the anisotropic elastic moduli, calculated by finite element analysis (FEA), were evaluated and compared.Results: The distribution of trabecular orientation suggested that longitudinal plates and transverse rods dominate at all three anatomic sites. aBV/TV along each axis, in general, showed a better correlation with the axial elastic modulus (r(2) = 0.95 similar to 0.99) compared with BV/TV (r(2) = 0.93 similar to 0.94). The plate-associated morphological parameters generally showed higher correlations with the corresponding standard morphological parameters than the rod-associated parameters. Multiple linear regression models of six elastic moduli with individual trabeculae segmentation (ITS)-based morphological parameters (adjusted r(2) = 0.95 similar to 0.98) performed equally well as those with standard morphological parameters (adjusted r(2) = 0.94 similar to 0.97) but revealed specific contributions from individual trabecular plates or rods.Conclusions: The ITS-based morphological analyses provide a better characterization of the morphology and trabecular orientation, of trabecular bone. The axial loading of trabecular bone is mainly sustained by the axially aligned trabecular bone volume. Results suggest that trabecular plates dominate the overall elastic properties of trabecular bone.