Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature.
Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature.
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DOI：
10.3174/ajnr.a4287
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Cha S
中科院分区：
文献类型：
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作者：
Mabray MC;Glastonbury CM;Mamlouk MD;Punch GE;Solomon DA;Cha S
恶性神经胶质瘤的特征是肿瘤细胞的浸润性生长，包括沿着白色物质束生长。这可能导致临床颅神经病变，因为颅神经直接受累，而不是软脑膜沿沿着颅神经扩散。直接累及颅神经III-XII的胶质瘤很罕见，2014年之前的文献中仅报告了11例病例，其中8例有影像学检查。我们提出了另外八个病例证明脑神经胶质瘤直接浸润。与对侧神经相比，不对称的脑池神经扩张的平均受累长度为9.4 mm。根据我们的病例系列，识别胶质瘤直接累及颅神经的关键影像学特征是检测脑桥脑或中脑的轴内肿块，该肿块与邻近颅神经的扩张、信号异常和/或增强直接相关。
Malignant gliomas are characterized by infiltrative growth of tumor cells, including along white matter tracts. This may result in clinical cranial neuropathy due to direct involvement of a cranial nerve rather than by leptomeningeal spread along cranial nerves. Gliomas directly involving cranial nerves III-XII are rare with only eleven cases reported in the literature prior to 2014, including eight with imaging. We present eight additional cases demonstrating direct infiltration of a cranial nerve by glioma. Asymmetric cisternal nerve expansion as compared to the contralateral nerve was noted with a mean length of involvement of 9.4 mm. Based on our case series, the key imaging feature to recognize direct cranial nerve involvement by a glioma is the detection of an intra-axial mass in the pons or midbrain that is directly associated with expansion, signal abnormality, and/or enhancement of the adjacent cranial nerve(s).