Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: Fatty acid composition of erythrocyte membrane lipids
Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: Fatty acid composition of erythrocyte membrane lipids
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DOI：
10.1203/00006450-199712000-00017
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发表时间：
1997-12-01
影响因子：
3.6
通讯作者：
Lien, EL
中科院分区：
文献类型：
--
作者：
Clandinin, MT;VanAerde, JE;Lien, EL
早产儿对长链多不饱和必需脂肪酸花生四烯酸（AA）和二十二碳六烯酸（DHA）的营养需求尚未明确定义。本研究评估了出生体重小于2.3 kg的早产儿，他们喂食了不含AA和DHA的商业配方奶粉（Preemie SMA（R）），并将该对照组与喂食含有0.32 - 1.1% AA和0.24 - 0.76% DHA的三种配方奶粉之一的类似婴儿组进行了比较。一组类似的婴儿喂养他们的母亲的母乳和母乳强化剂（当指示）也进行了研究。红细胞膜磷脂分离的血液样品收集在12日龄和4周的喂养后。与母乳或含AA和DHA的婴儿配方奶粉喂养的婴儿相比，喂养不含AA和DHA的配方奶粉的婴儿红细胞磷脂酰胆碱中AA水平降低，磷脂酰乙醇胺中DHA水平降低。添加AA和DHA水平增加的婴儿配方奶粉在红细胞膜磷脂中发现的AA和DHA水平方面产生了明显的剂量反应。从膜磷脂脂肪酸组成的比较中可以看出，0.32- 1.1%AA和0.24- 0.76%DHA的配方水平提供了足够的这些脂肪酸水平，以获得与母乳喂养的婴儿的大多数脂质组分相似的脂肪酸组成。
The nutritional requirements of preterm infants for the long chain polyunsaturated essential fatty acids, arachidonic acid (AA) and docosahexaenoic acid (DHA), have not been clearly defined. The present study evaluated preterm infants of less than 2.3 kg birth weight fed a commercial formula (Preemie SMA (R)) devoid of AA and DHA and compared this control group with similar infant groups fed one of three formulas containing a range of 0.32 to 1.1% AA and 0.24 to 0.76% DHA. An analogous group of infants fed their mothers' breast milk and a breast milk fortifier (when indicated) was also studied. Erythrocyte membrane phospholipids were isolated from blood samples collected at 12 d of age and after a further 4 wk of feeding. Infants fed the formula without AA and DHA showed a reduction in AA level in erythrocyte phosphatidylcholine, and a reduced level of DHA in phosphatidylethanolamine in comparison with infants fed breast milk or infant formula containing AA and DHA. Supplementing infant formula with increasing levels of AA and DHA produced a clear dose response in the levels of AA and DHA found in erythrocyte membrane phospholipids. From comparison of membrane phospholipid fatty acid composition it appears that a formula level of 0.32-1.1% AA and 0.24-0.76% DHA provides sufficient levels of these fatty acids to achieve a similar fatty acid composition to that of infants fed human milk for most of the lipid fractions examined.