Influence of a perfusing bath on the foot of the cardiac action potential.
Influence of a perfusing bath on the foot of the cardiac action potential.
复制标题
灌注浴对足部心脏动作电位的影响。
DOI：
10.1161/01.res.86.2.e19
复制
发表时间：
2000
影响因子：
20.1
通讯作者：
Roth,BJ
中科院分区：
文献类型：
--
作者：
Roth,BJ
—Recently, Spach et al (Circ Res. 1998;83:1144–1164) measured the transmembrane action potential 150 to 200 μm below the tissue surface during longitudinal and transverse propagation. They found that “during longitudinal propagation there was initial slowing of Vm[action potential] foot that resulted in deviations from a simple exponential… ” (p 1144). They attributed this behavior to the effects of capillaries on propagation. The purpose of this commentary is to show that the perfusing bath plays an important role in determining the time course of the action potential foot, even when the transmembrane potential is measured 150 μm below the tissue surface. Using numerical simulations based on the bidomain model, we find that the action potential foot for transverse propagation is nearly exponential (τfoot=314 μs). For longitudinal propagation, the action potential foot is not exponential because of an initial slowing (best-fit τfoot=483 μs). We conclude that the perfusing bath must be taken into account when interpreting data showing differences in the shape of the action potential foot with propagation direction, even if the transmembrane potential is measured 150 μm below the tissue surface. The full text of this article is available at http://www.circresaha.org.
