Autoregulation of renal blood flow in the puppy.
Autoregulation of renal blood flow in the puppy.
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小狗肾血流量的自动调节。
DOI：
10.1152/ajplegacy.1975.229.4.983
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
G. Eisner
中科院分区：
文献类型：
--
作者：
P. Jose;L. Slotkoff;S. Montgomery;P. Calcagno;G. Eisner
研究了未成熟肾脏自动调节血流的能力。通过电磁流量计测量肾血流量。在六只小狗中，通过将[1-肌氨酸，8-丙氨酸]血管紧张素II（抗AII）注射到肾动脉中选择性阻断血管紧张素II（AII）的肾内作用并没有改变肾血流量。在选择性肾 AII 阻断期间，静脉注射 AII 使灌注压从 76 +/- 2 mmHg 升高至 100 +/- 6 mmHg。肾血流量从每分钟 1.59 +/- 0.29 增加到 1.98 +/- 0.59 ml/g 肾，但尽管动脉压持续升高，但在 40 秒内恢复到控制水平。在另一组七只小狗中，尽管主动脉收缩将肾灌注压降低至 60 mmHg，但肾血流量仍保持恒定。在这七只小狗中，有两只的肾内抗 AII 并没有消除自动调节。幼犬肾血流量的自动调节不受血管紧张素抑制的影响。肾素-血管紧张素系统似乎不参与幼犬肾血流的正常调节。
The ability of the immature kidney to autoregulate blood flow was investigated. Renal blood flow was measured by electromagnetic flowmeter. In six puppies, selective blockade of the intrarenal effects of angiotensin II (AII) by [1-sarcosine, 8-alanine]angiotensin II (anti-AII) administered into the renal artery did not change renal blood flow. During selective renal AII blockade, intravenous AII raised perfusion pressure from 76 +/- 2 to 100 +/- 6 mmHg. Renal blood flow increased from 1.59 +/- 0.29 to 1.98 +/- 0.59 ml/g kidney per min, but returned to control levels within 40 s in spite of persistent arterial pressure elevation. In another group of seven puppies, renal blood flow remained constant despite reduction of renal perfusion pressure by aortic constriction to 60 mmHg. In two of these seven puppies intrarenal anti-AII did not abolish autoregulation. Autoregulation of renal blood flow occurs in the puppy and is not influenced by inhibition of angiotensin. The renin-angiotensin system does not appear to be involved in the normal regulation of renal blood flow in the puppy.