CYTOKINE SECRETION IN ACUTE SHIGELLOSIS IS CORRELATED TO DISEASE-ACTIVITY AND DIRECTED MORE TO STOOL THAN TO PLASMA
CYTOKINE SECRETION IN ACUTE SHIGELLOSIS IS CORRELATED TO DISEASE-ACTIVITY AND DIRECTED MORE TO STOOL THAN TO PLASMA
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DOI：
10.1093/infdis/171.2.376
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发表时间：
1995-02-01
影响因子：
6.4
通讯作者：
LINDBERG, AA
中科院分区：
文献类型：
--
作者：
RAQIB, R;WRETLIND, B;LINDBERG, AA
采用酶免疫法（EIA），对60例急性志贺菌病成人腹泻发病后不同时间（0-45天）的粪便和血浆细胞因子水平进行了研究。细胞因子水平与疾病的严重程度相关。严重疾病患者的粪便中促炎细胞因子水平在疾病发作时达到峰值（P <0.05）。与此相反，干扰素-γ（IFN-γ）的水平，在疾病发作时，抑郁症，逐步增加，在恢复阶段。同时获得的血浆细胞因子水平比粪便中的水平低100倍。志贺氏菌流行区对照组（n = 42）的粪便和血浆中IFN-γ和白细胞介素-1受体拮抗剂水平持续显著升高。宿主对志贺氏菌病防御活性的缺乏可能与IFN-γ的延迟恢复有关。这种细胞因子可能在消除感染和发展对志贺氏菌病的免疫力方面发挥重要作用。
Stool and plasma cytokine levels in 60 adults with acute shigellosis were studied by EIA at various intervals (0-45 days) after onset of diarrhea. Cytokine levels correlated with severity of disease. Significantly higher levels of proinflammatory cytokines peaked at onset of disease in stool of patients with severe disease (P < .05). In contrast, interferon-gamma (IFN-gamma) levels, depressed at disease onset, progressively increased during the convalescent stage. Concomitantly obtained plasma cytokine levels were 100 times lower than levels in stool. Controls in Shigella-endemic areas (n = 42) had persistently significantly higher levels of IFN-gamma and interleukin-1 receptor antagonist in both stool and plasma. The lack of host defense activity against shigellosis may be linked to delayed recovery of IFN-gamma. This cytokine may play an important role in elimination of the infection and development of immunity against shigellosis.