The prosubiculum in the human hippocampus: A rostrocaudal, feature-driven, and systematic approach.
The prosubiculum in the human hippocampus: A rostrocaudal, feature-driven, and systematic approach.
复制标题
人类海马体中的前臂：一种特征驱动的、系统性的吻尾方法。
DOI：
10.1002/cne.25604
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Augustinack,JeanC
中科院分区：
文献类型：
--
作者：
Rosenblum,EmmaW;Williams,EmilyM;Champion,SamanthaN;Frosch,MatthewP;Augustinack,JeanC
海马亚区前下丘（prosubfield prosubiculum, ProS）是小鼠、猴子和人类的一个保守的神经解剖区域。该区域位于CA1和下骨（Sub）之间，尤其对其边界缺乏共识；报道对其特征和位置的描述各不相同。在这篇报告中，我们回顾、完善并评估了将pro与其相邻子领域区分开来的四个细胞结构特征：(1)小神经元，(2)轻度染色神经元，(3)浅层聚集神经元，以及(4)细胞稀疏区。所有病例均有ProS （n= 10）。检查ProS的细胞结构特征和位置，从头部前部到海马的身体。最常见的特征是小锥体神经元，它们与大锥体神经元混杂在一起。我们定量测量了ProS锥体神经元，结果显示（平均，锥体基部宽度= 14.31µm,n= 400每个子场）。CA1神经元平均15.57µm， Sub神经元平均15.63µm，与ProS相比差异有统计学意义（Kruskal-Wallis检验，p< 0.0001）。观察到的其他三个特征是轻度染色的神经元，聚集的神经元和细胞稀疏区。综上所述，这些发现表明，ProS是一个独立的子领域，可能对更广泛的相互连接的海马体网络有不同的功能贡献。我们的研究结果表明，ProS是一个细胞结构变化的子领域，无论是在特征上还是在个体之间。pro在功能和个人方面的多样化架构可以解释长期以来识别这一子领域的复杂性。
The hippocampal subfield prosubiculum (ProS), is a conserved neuroanatomic region in mouse, monkey, and human. This area lies between CA1 and subiculum (Sub) and particularly lacks consensus on its boundaries; reports have varied on the description of its features and location. In this report, we review, refine, and evaluate four cytoarchitectural features that differentiate ProS from its neighboring subfields: (1) small neurons, (2) lightly stained neurons, (3) superficial clustered neurons, and (4) a cell sparse zone. ProS was delineated in all cases (n= 10). ProS was examined for its cytoarchitectonic features and location rostrocaudally, from the anterior head through the body in the hippocampus. The most common feature was small pyramidal neurons, which were intermingled with larger pyramidal neurons in ProS. We quantitatively measured ProS pyramidal neurons, which showed (average, width at pyramidal base = 14.31 µm,n= 400 per subfield). CA1 neurons averaged 15.57 µm and Sub neurons averaged 15.63 µm, both were significantly different than ProS (Kruskal–Wallis test,p< .0001). The other three features observed were lightly stained neurons, clustered neurons, and a cell sparse zone. Taken together, these findings suggest that ProS is an independent subfield, likely with distinct functional contributions to the broader interconnected hippocampal network. Our results suggest that ProS is a cytoarchitecturally varied subfield, both for features and among individuals. This diverse architecture in features and individuals for ProS could explain the long‐standing complexity regarding the identification of this subfield.