Recent progresses in the accumulation of metal ions into the apo-ferritin cage: Experimental and theoretical perspectives
Recent progresses in the accumulation of metal ions into the apo-ferritin cage: Experimental and theoretical perspectives
复制标题
金属离子在脱铁铁蛋白笼中积累的最新进展：实验和理论观点
DOI：
10.1016/j.poly.2019.03.048
复制
发表时间：
2019-11-01
期刊：
影响因子：
2.6
通讯作者：
Ueno, Takafumi
中科院分区：
文献类型：
--
作者：
Maity, Basudev;Hishikawa, Yuki;Ueno, Takafumi
铁蛋白是一种自组装的24元蛋白质笼子，自然是为储存铁而设计的。除铁外，载铁蛋白笼模板可以容纳各种非天然金属底物，如金属离子、金属配合物和有机分子。由于这一特性，载铁蛋白模板被用于制备无机纳米材料，包括量子点、金属纳米颗粒、金属氧化物等。虽然目前的研究主要集中在制备方面，但对金属离子沉积、易位、岩心形成等纳米材料形成的基础尚未明确。因此，研究具有详细配位结构的铁蛋白笼中金属离子的固定过程是材料化学领域的一个重要课题，可以在了解特定金属-蛋白质相互作用的基础上开发生物启发纳米材料。到目前为止，除了铁之外，只有有限的报道，用x射线晶体学详细描述了金属离子的积累。此外，理论计算提供了重要的信息，特别是金属离子积累过程的动力学以及氨基酸侧链的构象变化。在此背景下，本文综述了金属离子积累过程的最新研究进展，以期设计和构建新型铁蛋白基生物纳米材料。(C) 2019 Elsevier Ltd.版权所有。
Ferritin is a self-assembled 24-mer protein cage which is naturally designed for iron storage. Other than iron, the apo-ferritin cage template can accommodate various non-natural metal substrates such as metal ions, metal complexes, and organic molecules. Because of this property, the apo-ferritin template is utilized for preparing inorganic nanomaterials which include quantum dot, metal nanoparticle, metal oxide etc. Although current studies are largely focusing on preparation, the basis of nanomaterial formations such as metal ion deposition, translocation, core formation etc. are not clarified. Therefore, studying the process of metal ions immobilization in ferritin cage with detailed coordination structures is an important topic in the area of material chemistry to develop bioinspired nanomaterials with a fundamental understanding of specific metal-protein interaction. Until now, there are only a limited number of reports except iron, which describes the metal ions accumulation with details characterization by X-ray crystallography. In addition, theoretical calculations are providing important information, particularly the dynamics of the accumulation process of metal ions as well as conformational changes in the amino acid side chains. Under this background, the current review highlights the recent and significant progress on the metal ion accumulation process in order to design and construct novel ferritin-based bionanomaterials. (C) 2019 Elsevier Ltd. All rights reserved.