Emerging Functional Differences between the Synaptotagmin and Ferlin Calcium Sensor Families.

Emerging Functional Differences between the Synaptotagmin and Ferlin Calcium Sensor Families.
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DOI:
10.1021/acs.biochem.7b00928
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发表时间:
2017-12-12
期刊:
影响因子:
2.9
通讯作者:
Johnson CP
Johnson CP
中科院分区:
生物学3区
文献类型:
--
作者:
Johnson CP

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ferlin家族蛋白已成为钙触发的膜融合和分裂事件的多C2结构域调节剂。虽然最初确定共享的突触结合蛋白家族的钙传感器的成员的许多功能,ferlin在最近的研究中已被发现直接与非神经元的电压门控钙通道和成核的膜运输蛋白复合物的组装,功能,区分他们从突触结合蛋白家族的更好的研究成员。在这里,我们强调了一些最近的研究结果,推进了我们的理解ferlins和他们的功能差异与synaptotagmin家庭。
The ferlin family proteins have emerged as multi-C2 domain regulators of calcium-triggered membrane fusion and fission events. While initially determined to share many of the features of members of the synaptotagmin family of calcium sensors, ferlins in more recent studies have been found to interact directly with non-neuronal voltage-gated calcium channels and nucleate the assembly of membrane-trafficking protein complexes, functions that distinguish them from the more well studied members of the synaptotagmin family. Here we highlight some of the recent findings that have advanced our understanding of ferlins and their functional differences with the synaptotagmin family.
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