Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia - a case report
Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia - a case report
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DOI：
10.1017/s0022215100138551
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发表时间：
1997-08-01
影响因子：
1.7
通讯作者：
Schumacher, U
中科院分区：
文献类型：
--
作者：
Adam, EC;Schumacher, DU;Schumacher, U
从囊性纤维化患者的鼻息肉中获取的纤毛搏动频率测量值与对照鼻息肉的纤毛搏动频率测量值相似。添加由铜绿假单胞菌产生的纤毛毒性凝集素停止了纤毛的跳动。该反应可通过凝集素与其抑制剂岩藻糖的前孵育来阻断。就像在控制。在纤毛减慢后加入岩藻糖导致在24小时内恢复正常纤毛搏动。这表明在该患者中观察到的Δ F508 CF突变不影响纤毛搏动，并表明在铜绿假单胞菌感染的早期阶段用岩藻糖治疗可能对囊性纤维化患者有利。
The ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced by Pseudomonas aeruginosa stopped the beating of the cilia as in the controls. This reaction could be blocked by the pro-incubation of the lectin with its inhibitor fucose. As in the control. the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of a Pseudomonas aeruginosa infection could be advantageous for cystic fibrosis patients.