Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes
Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes
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DOI：
10.1021/acs.macromol.8b02758
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发表时间：
2019-04-09
期刊：
影响因子：
5.5
通讯作者：
Gallei, Markus
中科院分区：
文献类型：
--
作者：
Schoettner, Sebastian;Brodrecht, Martin;Gallei, Markus
生物系统特异识别、分类和处理分子的非凡能力鼓励了新型生物膜和界面的发展。在此，我们重点研究了两亲性聚苯乙烯-嵌段聚（2-羟乙基甲基丙烯酸酯）（PS-b-PHEMA）与氨基酸甘氨酸的功能化，产生具有伯胺功能的极性嵌段。尺寸排除色谱（SEC）， H-1溶液核磁共振和N-15固体核磁共振波谱证明了对定制嵌段共聚物（BCP）合成和功能化的出色控制。首次将含伯胺的bcp用于自组装和非溶剂诱导相分离（SNIPS）工艺，制备了等孔和整体不对称膜。通过扫描电镜（SEM）、原子力显微镜（AFM）和ph相关的水通量测量，得到了直径为19圈的六边形开孔。此外，伯胺进行了方便的后修饰。例如，（荧光）染料分子可以很容易地融入到膜结构中，并且可以在膜的内孔壁上完成肽的合成。这些新颖的、定制的多孔材料将为新一代的BCP膜铺平道路，这些膜在界面上含有生物启发的部分和功能。
The remarkable ability of biological systems to specifically recognize, sort, and process molecules encourages the development of novel bio-inspired membranes and interfaces. Herein, we focus on the functionalization of amphiphilic polystyrene-block-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) with the amino acid glycine yielding polar block segments with primary amine functionalities. Excellent control over the tailored block copolymer (BCP) synthesis and functionalization is proven by size exclusion chromatography (SEC), H-1 solution NMR, and N-15 solid state NMR spectroscopy. For the first time, BCPs containing primary amines were used for the self-assembly and non-solvent induced phase separation (SNIPS) process for the preparation of isoporous and integral asymmetric membranes. Hexagonally arranged open pores with diameters of 19 rim were obtained as shown by scanning electron microscopy (SEM), atomic force microscopy (AFM), and pH-dependent water flux measurements. Additionally, the primary amine was subjected to convenient postmodification protocols. For instance, (fluorescent) dye molecules could be easily incorporated into the membrane structure, and peptide synthesis on the inner pore wall of the membrane could be accomplished. These novel and tailored porous materials will pave the way to a new generation of BCP membranes containing bio-inspired moieties and functionalities at the interfaces.