Synergism of cortisol and thyrotropin-releasing hormone in lung maturation in fetal sheep.
Synergism of cortisol and thyrotropin-releasing hormone in lung maturation in fetal sheep.
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皮质醇和促甲状腺素释放激素在胎羊肺成熟中的协同作用。
DOI：
10.1152/jappl.1988.65.4.1880
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lee,CC
中科院分区：
文献类型：
--
作者：
Liggins,GC;Schellenberg,JC;Manzai,M;Kitterman,JA;Lee,CC
研究了28只妊娠128天的胎羊分别输注皮质醇和促甲状腺激素释放激素（TRH）对肺压力-容积关系和饱和磷脂酰胆碱（SPC）浓度的影响。四组每组7个胎儿分别输注生理盐水（156小时）、TRH（25微克/小时，60秒脉冲，持续156小时）、TRH（156小时）联合皮质醇（1毫克/小时，持续84小时）或皮质醇（84小时）。皮质醇对SPC浓度没有影响，而TRH和皮质醇加TRH均可增加灌洗液中SPC的浓度，但对肺组织没有影响。皮质醇和TRH均未显著影响肺扩张性[V40]；分别为0.64 +/- 0.04和0.57 +/- 0.10 (SE) ml/g，对照组为0.41 +/- 0.03 ml/g)或稳定性（V5; 0.24 +/- 0.01和0.35 +/- 0.07 ml/g，对照组为0.24 +/- 0.03 ml/g），而两种激素联合治疗与V40 （1.70 +/- 0.16 ml/g）和V5 （1.03 +/- 0.15 ml/g）增加四倍相关。由于皮质醇、三碘甲状腺原氨酸和雌二醇-17 β浓度的升高（皮质醇治疗）对V40和V5没有影响，而与催乳素水平升高相关的类似激素变化（皮质醇加TRH治疗）有明显的影响，我们得出结论，催乳素在皮质醇和TRH的协同作用中起着重要作用。
The effects of fetal infusions of cortisol and thyrotropin-releasing hormone (TRH) singly and together on pressure-volume relationships and saturated phosphatidylcholine (SPC) concentrations in the lungs were studied in 28 fetal sheep delivered at 128 days of gestation. Four groups each of 7 fetuses were infused with either saline (for 156 h), TRH (25 micrograms/h in 60-s pulses for 156 h), TRH (for 156 h) combined with cortisol (1 mg/h for 84 h), or cortisol (for 84 h). Cortisol had no effect on SPC concentrations, whereas both TRH and cortisol plus TRH increased the concentration of SPC in lavage fluid but not lung tissue. Neither cortisol nor TRH significantly affected lung distensibility [V40; 0.64 +/- 0.04 and 0.57 +/- 0.10 (SE) ml/g, respectively, vs. 0.41 +/- 0.03 ml/g in controls] or stability (V5; 0.24 +/- 0.01 and 0.35 +/- 0.07 ml/g vs. 0.24 +/- 0.03 ml/g), whereas treatment with a combination of the two hormones was associated with a fourfold increase in V40 (1.70 +/- 0.16 ml/g) and V5 (1.03 +/- 0.15 ml/g). Since raised concentrations of cortisol, triiodothyronine, and estradiol-17 beta (treatment with cortisol) had no effect on V40 and V5, whereas similar hormonal changes associated with elevated prolactin levels (treatment with cortisol plus TRH) had marked effects, we conclude that prolactin plays an essential part in the synergism of cortisol and TRH.