β2-glycoprotein I and LDL-receptor family members
β2-glycoprotein I and LDL-receptor family members
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DOI：
10.1016/j.thromres.2004.06.015
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发表时间：
2004-01-01
影响因子：
7.5
通讯作者：
Derksen, RHWM
中科院分区：
文献类型：
--
作者：
de Groot, PG;van Lummel, M;Derksen, RHWM
血浆中抗磷脂抗体的存在是血栓栓塞并发症的危险因素。然而，在体外，同样的抗体可以延长凝血试验中的凝血时间，这是出血倾向的经典标志。多年来，这个矛盾困扰着许多科学家。我们现在知道，抗磷脂抗体这一术语包含了不同种类的抗体，而且越来越多的证据表明，只有抗磷脂抗体亚群与临床并发症有关。结合抗磷脂抗体、蛋白β 2-糖蛋白I和细胞表面之间复杂相互作用的新信息，为理解该综合征的病理开辟了新的途径。(c) 2004 Elsevier Ltd.版权所有。
The presence of antiphospholipid antibodies in plasma is a risk factor for thromboembolic complications. In vitro, however, the same antibodies can prolong clotting times in coagulation assays, a classic marker for a bleeding tendency. For years this contradiction puzzles many scientists. We now know that the term antiphospholipid antibodies comprises a heterogeneous population of antibodies and there is growing evidence that only subpopulations of anti phospholipid antibodies are relevant for the clinical complication. In combination with new information on the complex interaction between antiphospholipid antibodies, the protein beta 2-Glycoprotein I, and cellular surfaces have opened new avenues for the understanding of the pathology of this syndrome. (c) 2004 Elsevier Ltd. All rights reserved.