Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions.
Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions.
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在具有两种以上治疗条件的临床试验中将患者有效分配至治疗细胞。
DOI：
10.1176/ajp.155.10.1446
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Cohen,J
中科院分区：
文献类型：
--
作者：
Woods,SW;Sholomskas,DE;Shear,MK;Gorman,JM;Barlow,DH;Goddard,AW;Cohen,J
临床试验通常将患者分配到相同大小的治疗组。作者提出，它可能是更有效的分配不平等的比例，总样本量的治疗时，两个以上的treatments.MethodThis建议是说明了两个例子。一项研究涉及三种治疗方法的比较，并使用了二分分类结果。另一个涉及三种治疗的比较，并使用连续的measure.ResultsIn两个例子中，一个相当大的效率增加是通过减少分配到安慰剂细胞的患者数量来实现的。
ObjectiveClinical trials generally allocate patients to equal-sized treatment groups. The authors propose that it may be more efficient to allocate unequal proportions of the total sample size to treatments when more than two treatments are being compared.MethodThis proposal is illustrated with two examples. One involved a comparison of three treatments and used a dichotomous categorical outcome. The other involved comparison of three treatments and used a continuous measure.ResultsIn both examples, a considerable increase in efficiency was realized by reducing the number of patients assigned to the placebo cell.ConclusionsUnequal allocation of patients to treatments should be considered when more than two groups are compared.Am J Psychiatry 1998; 155: 1446-1448