Does body size account for gender differences in femur bone density and geometry?
Does body size account for gender differences in femur bone density and geometry?
复制标题
DOI：
10.1359/jbmr.2001.16.7.1291
复制
发表时间：
2001-07-01
影响因子：
6.2
通讯作者：
Orwoll, ES
中科院分区：
文献类型：
--
作者：
Looker, AC;Beck, TJ;Orwoll, ES
在多大程度上，男性更大的骨骼强度是由更大的骨量与更大的骨骼尺寸成比例引起的尚不清楚，主要是因为男性更大的整体体型使得骨骼测量的直接比较变得困难，我们研究了从5623名20岁以上非西班牙裔白人中收集的股骨颈（FN）面积骨密度（BMD）值的性别差异第三次全国健康和营养调查（NHANES III，1988-1994）对测量的身高和体重进行校正前后，补充常规的区域BMD数据（Hologic QDR 1000），测量区域BMD和几何特性（骨膜下宽度、截面模量和皮质厚度），使用结构分析程序在穿过FN和近端轴的狭窄“横截面”区域进行测量。在调整主体尺寸之前，男性在三个测量点的所有变量值均显著高于女性（p < 0.0001），调整体型可减少所有变量的性别差异，但对BMD的影响更大（男性高1-8%）比几何形状（男性高5-17%），当按年龄检查时，除骨膜下宽度外，老年组的所有变量的性别差异均显著更大。我们的结论是，虽然身体大小的差异可能占大部分的区域BMD的差异，男性和女性之间，男性骨骼仍然更大的方式，表明更大的骨强度。这些差异可能对降低男性骨折风险起到重要作用。
The extent to which greater bone strength in men is caused by proportionately greater bone mass versus bigger bone size is not clear, primarily because the larger overall body size of men has made direct comparisons of skeletal measures difficult, We examined gender differences in femur neck (FN) areal bone mineral density (BMD) values collected from 5623 non-Hispanic whites aged 20+ years in the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) before and after correction for measured height and weight, We supplemented the conventional areal BMD data (Hologic QDR 1000) with measurements of areal BMD and geometric properties (subperiosteal width, section modulus, and cortical thickness) made at narrow "cross-sectional" regions traversing the FN and the proximal shaft using a structural analysis program, Before body size adjustment, men had significantly higher values than women for all variables at the three measurement sites (p < 0.0001), Adjustment for body size reduced the differences between the sexes for all variables but had a greater effect on BMD (1-8% higher in men) than on geometry (5-17% higher in men), When examined by age, the sex discrepancy was significantly greater in the older group for all variables except subperiosteal widths. We conclude that although body size difference may account for most of the areal BMD difference between men and women, male bones are still bigger in ways that suggest greater bone strength. These differences may contribute importantly to lower fracture risk in men.