Synthesis of Multifunctional 3‐Amino‐4‐phosphono‐2‐quinolinones via Regioselective Ring Enlargement of Imino Isatins
Synthesis of Multifunctional 3‐Amino‐4‐phosphono‐2‐quinolinones via Regioselective Ring Enlargement of Imino Isatins
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DOI：
10.1002/adsc.201400652
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发表时间：
2014-12
影响因子：
5.4
通讯作者：
Xiaojin Wen;J. Chen;Yungui Peng
中科院分区：
文献类型：
--
作者：
Xiaojin Wen;J. Chen;Yungui Peng
Multifunctional 3‐amino‐4‐dialkylphosphono‐2‐quinolinones have been prepared by “one‐pot” nucleophilic addition and regioselective ring enlargement of imino isatins. The addition reaction between imino isatins and dialkyl (diazomethyl)phosphonate proceeds smoothly using potassium carbonate as a catalyst, and a subsequent regioselective ring expansion promotes by salicylic acid to afford the desired products in high yields.
