EXPERIMENTALLY INDUCED VISUAL PROJECTIONS INTO AUDITORY THALAMUS AND CORTEX
EXPERIMENTALLY INDUCED VISUAL PROJECTIONS INTO AUDITORY THALAMUS AND CORTEX
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DOI：
10.1126/science.2462279
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发表时间：
1988-12-09
期刊：
影响因子：
56.9
通讯作者：
ROE, AW
中科院分区：
文献类型：
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作者：
SUR, M;GARRAGHTY, PE;ROE, AW
在新生雪貂中，通过减少一侧半球的视网膜轴突目标并为听觉丘脑中的这些纤维创建替代末端空间，已诱导视网膜细胞投射到内侧膝状体核（主要听觉丘脑核）中。内侧膝状核中的许多细胞随后受到视觉驱动，具有较大的感受野，并接收来自体细胞较小且传导速度较慢的视网膜神经节细胞的输入。初级听觉皮层中也可以记录具有长传导潜伏期和大对侧感受野的视觉细胞。听觉皮层中的一些视觉细胞具有方向选择性或具有类似于初级视觉皮层中的复杂细胞的定向感受野。因此，功能性视觉投射可以被路由到高等哺乳动物的非视觉结构中，这表明感觉丘脑核或皮质区域的形态可能由其在发育过程中的输入所指定。
Retinal cells have been induced to project into the medial geniculate nucleus, the principal auditory thalamic nucleus, in newborn ferrets by reduction of targets of retinal axons in one hemisphere and creation of alternative terminal space for these fibers in the auditory thalamus. Many cells in the medial geniculate nucleus are then visually driven, have large receptive fields, and receive input from retinal ganglion cells with small somata and slow conduction velocities. Visual cells with long conduction latencies and large contralateral receptive fields can also be recorded in primary auditory cortex. Some visual celsl in auditory cortex are direction selective or have oriented receptive fields that resemble those of complex cells in primary visual cortex. Thus, functional visual projections can be routed into nonvisual structures in higher mammals, suggesting that the modality of a sensory thalamic nucleus or cortical area may be specified by its inputs during development.