Non-antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia.
Non-antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia.
复制标题
由产毒素梭菌引起的非抗生素相关性伪膜性结肠炎。
DOI：
10.7326/0003-4819-92-6-798
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发表时间：
1980
影响因子：
39.2
通讯作者：
John G. Bartlett
中科院分区：
文献类型：
--
作者：
Arnold Wald;Harvey Mendelow;John G. Bartlett
摘要 在 4 名因抗生素引起的伪膜性结肠炎患者和 54 名抗生素相关性腹泻患者的粪便标本中，均检测到一种在组织培养中产生细胞毒性的物质。当将这些粪便注射到仓鼠体内时，也会引起小肠结肠炎。每次，组织培养中的细胞毒性和仓鼠小肠结肠炎都通过气性坏疽抗毒素预处理来中和。从五种粪便中的四种中分离出梭菌菌株的肉汤培养物，可以重现组织培养物和仓鼠中的毒性。这些结果表明产毒素梭状芽胞杆菌是抗生素相关性伪膜性结肠炎的罪魁祸首。 (新英格兰医学杂志 298:531–534, 1978)
Abstract A substance producing cytotoxicity in tissue culture was detected in stool specimens from all of four patients with pseudomembranous colitis due to antibiotics and in one of 54 with antibiotic-associated diarrhea. These stools also caused enterocolitis when injected intracecally into hamsters. On each occasion, cytotoxicity in tissue culture and enterocolitis in hamsters were neutralized by pretreatment with gas-gangrene antitoxin. The toxicity in both tissue cultures and hamsters could be reproduced with broth cultures of clostridia strains isolated from four of the five stools. These results suggest that toxin-producing clostridia are responsible for antibiotic-associated pseudomembranous colitis. (N Engl J Med 298:531–534, 1978)