Protein phosphatases
Protein phosphatases
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DOI：
10.1016/0959-440x(95)80004-2
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发表时间：
1995-12-01
影响因子：
6.8
通讯作者：
Barford, D
中科院分区：
文献类型：
--
作者：
Barford, D
蛋白磷酸酶是使细胞磷蛋白去磷酸化的信号转导酶。最近确定的蛋白质酪氨酸和丝氨酸/苏氨酸磷酸酶的晶体结构表明，这些蛋白质采用不同的结构，并通过不同的酶促机制催化脱磷酸化反应。底物特异性和酶调节的基础也可以从这些晶体结构中获得。
Protein phosphatases are signal transducing enzymes that dephosphorylate cellular phosphoproteins. The recently determined crystal structures of protein tyrosine and serine/threonine phosphatases reveal that these proteins adopt distinct structures and catalyze dephosphorylation reactions by means of different enzymatic mechanisms. Insights into the basis for substrate specificity and enzyme regulation can also be gained from these crystal structures.