Evidence for the role of corticotropin-releasing factor in major depressive disorder.
Evidence for the role of corticotropin-releasing factor in major depressive disorder.
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DOI：
10.1016/j.neubiorev.2015.07.011
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发表时间：
2015-11
影响因子：
8.2
通讯作者：
Summers CH
中科院分区：
文献类型：
--
作者：
Waters RP;Rivalan M;Bangasser DA;Deussing JM;Ising M;Wood SK;Holsboer F;Summers CH
重度抑郁症（MDD）是一种破坏性疾病，影响全世界3亿多人，仅在欧洲联盟，其生产力和医疗保健损失估计就高达3800亿欧元。尽管大量的研究都是为了理解和治疗重度抑郁症，但仍然没有一种疗法被证明能够持续可靠地有效地阻断这种疾病的症状。最近分别使用遗传筛选和转基因啮齿动物进行的临床和临床前研究表明，CRF1基因和CRF1受体蛋白的中心表达在决定个体患重度抑郁症的风险方面发挥了重要作用。该基因在脑组织中广泛表达，并调节生物体对社会和环境压力源的即时和长期反应，这是重度抑郁症的主要原因。本文综述了CRF生理学的现状，以及它如何影响重度抑郁症相关症状的发生。此外，本综述还介绍了多个实验室的研究结果，这些研究结果作为国际行为神经科学学会（IBNS） 2014年年度会议上关于该主题的研讨会的一部分。在这篇综述中提出的观点和数据表明，在过去的几十年里，我们对重度抑郁症的理解取得了巨大的进步，并为开发新的治疗方法和检测方法提供了一条途径。
Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European Union alone. Although a wealth of research has been directed toward understanding and treating MDD, still no therapy has proved to be consistently and reliably effective in interrupting the symptoms of this disease. Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual’s risk of developing MDD. This gene is widely expressed in brain tissue, and regulates an organism’s immediate and long-term responses to social and environmental stressors, which are primary contributors to MDD. This review presents the current state of knowledge on CRF physiology, and how it may influence the occurrence of symptoms associated with MDD. Additionally, this review presents findings from multiple laboratories that were presented as part of a symposium on this topic at the annual 2014 meeting of the International Behavioral Neuroscience Society (IBNS). The ideas and data presented in this review demonstrate the great progress that has been made over the past few decades in our understanding of MDD, and provide a pathway forward toward developing novel treatments and detection methods for this disorder.