Mortality among tuberculosis patients in the Netherlands in the period 1993-1995
Mortality among tuberculosis patients in the Netherlands in the period 1993-1995
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DOI：
10.1183/09031936.98.11040816
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发表时间：
1998-04-01
影响因子：
24.3
通讯作者：
Nagelkerke, N
中科院分区：
文献类型：
--
作者：
Borgdorff, MW;Veen, J;Nagelkerke, N
本研究旨在估计荷兰结核病患者的超额死亡率，并确定与结核病相关的死亡率的危险因素。国家结核病登记册提供了 1993 年至 1995 年期间诊断的患者数据。根据年龄和年龄，结核病病例的超额死亡率是通过与全国死亡率进行比较来确定的。确定了风险因素，并使用 Cox 比例风险分析对混杂因素进行了调整。在 4,340 名诊断时存活的患者中，258 名患者在治疗期间死亡在 1 克以内。 1 年后 Kaplan-Meier 生存概率为 93%。结核病患者的标准化死亡率为8.3。死亡的独立危险因素是：性别；年龄;存在恶性肿瘤或人类免疫缺陷病毒 (HIV) 感染；酗酒或吸毒；结核病的定位；在所有死亡中，83% 发生在两个风险组中，其中 21% 为结核病患者：年龄大于或等于 65 岁的患者和患有 HIV 感染或患有恶性肿瘤的患者。荷兰的结核病患者的死亡风险显着增加，然而，对于年龄低于 65 岁且没有人类免疫缺陷病毒感染或恶性肿瘤的患者来说，预后非常好。
This study aimed to estimate excess mortality among tuberculosis patients in the Netherlands and identify risk factors far tuberculosis-associated mortality.The national tuberculosis register provided data on patients diagnosed in the period 1993-1995. Excess mortality in tuberculosis cases, according to age and ses, was determined by comparison with national mortality rates. Risk factors were identified and adjustment for confounders was carried out using Cox's proportional hazard analysis,Of 4,340 patients alive at diagnosis, 258 died within 1 gr while on treatment. The Kaplan-Meier survival probability after 1 yr was 93%. Tuberculosis patients had a standardized mortality ratio of 8.3. Independent risk factors for mortality were: gender; age; presence of a malignancy or human immunodeficiency virus (HIV) infection; addiction to alcohol or drugs; localization of tuberculosis; and the type of medical officer having made the diagnosis, Of all deaths, 83% occurred in two risk groups comprising 21% of tuberculosis patients: those aged greater than or equal to 65 yrs and those having HIV infection or a malignancy.Tuberculosis patients in the Netherlands are at a considerably increased risk of death, However, the prognosis is very good for those aged less than 65 yrs and without human immunodeficiency virus infection or a malignancy.