Nanosuspensions in drug delivery: recent advances, patent scenarios, and commercialization aspects.
Nanosuspensions in drug delivery: recent advances, patent scenarios, and commercialization aspects.
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DOI：
10.1615/critrevtherdrugcarriersyst.v28.i5.20
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发表时间：
2011
影响因子：
2.7
通讯作者：
Sandip S Chavhan;Kailash C. Petkar;K. Sawant
中科院分区：
文献类型：
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作者：
Sandip S Chavhan;Kailash C. Petkar;K. Sawant
由于纳米材料作为一种具有广泛应用前景的药物传递系统具有巨大的潜力，人们对纳米材料的制备和应用越来越感兴趣。最近，纳米系统作为一种解决溶解度问题的方法受到了人们的广泛关注，因为与脂质体和其他胶体药物载体相比，纳米系统具有成本效益和技术简单性。纳米混悬液已被证明是目前可用于提高低溶解度药物生物利用度的一种更好的替代方法。纳米混悬液已被广泛用于多种药物，并已通过各种途径（肠外、口服、肺、局部）对体外和体内应用进行了评估。它们也被用于药物靶向。不同的纳米混悬液制备方法及其应用已被报道并获得专利。事实上，基于纳米混悬液的产品在市场上和临床研究中的数量高于其他基于纳米技术的应用。本文综述了纳米混悬剂的配方、表征、应用以及纳米混悬剂的专利研究进展。
The interest in the preparation and application of nanometer-sized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving bioavailability of number of drugs with low solubility. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in vitro and in vivo applications by various routes: parenteral, oral, pulmonary, topical. They have also been used for drug targeting. Different preparation methods for nanosuspensions and their application are being reported and patented. In fact, the number of products based on nanosuspension in the market and under clinical study is higher than that of other nanotechnology-based applications. This article reviews the research and recent advances in formulation, characterization, application of nanosuspensions as well as patents on nanosuspension methods.