Lung clearance index and exercise capacity among children with bronchiectasis
Lung clearance index and exercise capacity among children with bronchiectasis
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支气管扩张儿童肺清除指数与运动能力
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
J. Tsanakas
中科院分区：
文献类型：
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作者：
E. Hatziagorou;Vasiliki Avramidou;F. Kirvassilis;Kalliopi Kontouli;S. Nikopoulos;J. Tsanakas
背景：在儿童支气管扩张症中，通过运动限制和肺清除指数(LCI)来评估疾病严重程度之间的关系的经验有限。目的：比较支气管扩张症患儿的LCI和运动能力。方法：对15例稳定期CF患儿、14例缓解期非CF支扩患儿和15例健康儿童少年进行最大负荷心肺运动试验，并进行LCI评定。结果：CF患儿平均年龄为13.7岁，平均FEV1预测率为74.4%。14例非CF型支气管扩张症患儿的平均年龄为13.8岁，平均FEV1的预测率为75.1%，健康儿童的平均年龄为13.6岁，平均FEV1为94.7%。在CF患者中，存在运动受限的证据，平均峰值有氧能力(V90峰值)预测为62.2%。在非慢性支气管扩张症患者中，有运动受限的证据，平均V90峰值为77.3%。慢性支气管炎和非慢性支气管扩张症患儿的平均V90峰值差异无统计学意义(p：0.06)。与健康儿童相比，CF患者的LCI显著增加(平均LCI为13.7)(p结论：运动试验和多次呼吸冲洗测量可以区分支扩儿童和健康儿童。然而，与非CF的支气管扩张症相比，CF患儿的疾病负担更为突出。
Background: In paediatric bronchiectasis, there has been limited experience on the relationship between disease severity, as assessed by exercise limitation and lung clearance index (LCI). Aim: To compare LCI and exercise capacity among children with bronchiectasis. Method: Fifteen stable children and adolescents with CF, 14 stable children with non-CF bronchiectasis and 15 healthy children and adolescents, participated in maximal incremental cardiopulmonary exercise testing using a cycle ergometer and they had an LCI assessment. Results: The CF children9s mean age was 13.7 years, mean FEV 1 74.4% predicted. The 14 non-CF bronchiectasis children9s mean age was 13.8 years, mean FEV 1 75.1% predicted and the healthy children9s mean age was 13.6 years, mean FEV1 94.7%. Among CF patients there was evidence of exercise limitation, with mean Peak Aerobic Capacity (V9Opeak) 62.2 % predicted. Among the non-CF bronchiectasis patients there was evidence of exercise limitation, with mean V9Opeak 77.3 % predicted. Mean V9Opeak did not differ significantly among children with CF and non-CF bronchiectasis (p: 0.06). LCI was significantly increased among CF patients (mean LCI 13.7), compared to healthy children (p Conclusions: Exercise testing and Multiple Breath Washout measurements can discriminate children with bronchiecatsis from healthy children. However, the burden of the disease is more prominent in children with CF compared with the non-CF bronchiectasis.