Immunological functions of aged human monocytes.
Immunological functions of aged human monocytes.
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衰老人单核细胞的免疫功能。
DOI：
10.1159/000163946
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Bakouche,O
中科院分区：
文献类型：
--
作者：
McLachlan,JA;Serkin,CD;Morrey-Clark,KM;Bakouche,O
衰老与感染和癌症发生率的增加有关，并且随着人们年龄的增长，他们开始表现出与年龄相关的免疫缺陷，统称为免疫衰老。为了确定年龄对人类单核细胞的影响，将“老年单核细胞”（从> 65岁的个体中分离出来）与“年轻单核细胞”（从-25岁的个体中分离出来）被脂多糖激活的能力进行了比较。我们的结果表明，老化的单核细胞在体外对肿瘤细胞的细胞毒性降低，白细胞介素（IL1）分泌减少（尽管没有观察到IL1前体产生减少），活性氧和氮中间体（ROI/RNI）释放减少，细胞内环磷酸腺苷水平增加以及蛋白激酶易位丧失。因此，衰老的单核细胞呈现出独特的免疫衰老特征。
Aging is associated with an increased occurrence of infection and cancer, and, as people age, they begin to exhibit age-related immune deficiencies, collectively termed immunosenescence. To determine the effects of age on human monocytes, ‘aged monocytes’ (isolated from individuals > 65 years of age) were compared with ‘young monocytes’ (isolated from individuals -25 years of age) for their ability to be activated by lipopolysaccharide. Our results show that aged monocytes display a decrease in their cytotoxicity against tumor cells in vitro, a decrease in interleukin (IL1) secretion (although no decrease in IL1 precursor production was observed), a decrease in reactive oxygen and nitrogen intermediate (ROI/RNI) release, an increase in intracellular levels of cyclic adenosine monophosphate and a loss of protein kinase translocation. Therefore, aged monocytes present distinct characteristics of immunosenescence.