Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
复制标题
DOI：
10.1016/s1535-6108(04)00081-9
复制
发表时间：
2004-04-01
期刊：
影响因子：
50.3
通讯作者：
Wang, XF
中科院分区：
文献类型：
--
作者：
Bao, SD;Ouyang, G;Wang, XF
与肿瘤转移相关的分子机制仍然知之甚少。在这里，我们报告，获得性表达骨膜蛋白的结肠癌细胞大大促进了结肠肿瘤的转移发展。骨膜蛋白在超过80%的人结肠癌中过表达，在转移性肿瘤中表达最高。骨膜蛋白表达通过防止癌细胞中应激诱导的凋亡和增加内皮细胞存活以促进血管生成来显著增强结肠癌的转移性生长。在分子水平上，骨膜蛋白通过α（v）β（3）整联蛋白激活Akt/PKB信号通路以增加细胞存活。这些数据表明，促进生存的功能是至关重要的骨膜蛋白，以促进结肠癌的肿瘤转移。
Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.